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| Status |
Public on Sep 20, 2018 |
| Title |
Genome-wide copy number analysis by Array CGH for the analysis of clonality of thoracic tumors |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Multiple synchronous and metachronous lung tumors are frequently encountered in patients with lung cancer. For treatment purposes it is important to determine, whether or not tumors are clonally related. In other words, whether multiple tumors in a patient are either metastases or multiple primaries. Previous reports show considerable discordance between histopathological and molecular comparison of tumor pairs. The purpose of this study is to compare genome-wide copy number analysis to the classical histological and clinicopathological routine for clonality analysis in a prospective cohort of patients with synchronous or metachronous tumors, of which at least one site occurred in the thorax.
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| Overall design |
Two-colour experiment experiment,tumor vs reference. Multiple cases with 2 or more tumors per case.
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| Contributor(s) |
Vincenten JP, van Essen HF, Bulkmans N, Krijgsman O, Grünberg K, Witte BI, Smit EF, Ylstra B, Thunnissen E |
| Citation(s) |
31618260 |
| Submission date |
Sep 18, 2016 |
| Last update date |
Oct 28, 2019 |
| Contact name |
Daoud Sie |
| E-mail(s) |
d.sie@vumc.nl
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| Phone |
+31 20 4442428
|
| Organization name |
Vrije Universiteit Medical Center
|
| Department |
Pathology
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| Lab |
Microarray Core Facility
|
| Street address |
De Boelelaan 1117
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| City |
Amsterdam |
| ZIP/Postal code |
1081 HV |
| Country |
Netherlands |
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| Platforms (4)
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| GPL8841 |
Agilent-014950 Human Genome CGH Microarray 4x44K (Probe Name version) |
| GPL15397 |
Agilent-023363 Human 180K UMCG_april09 (Probe Name version) |
| GPL16694 |
Agilent-022522 SurePrint G3 CGH array 4X180K (Probe Name version) |
| GPL18628 |
Agilent HD CGH Microarray (2X105K) Oxford design AMADID#019015 (Probe name version) |
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| Samples (190)
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| Relations |
| BioProject |
PRJNA343498 |
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