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Status |
Public on Oct 01, 2016 |
Title |
Small RNA Sequencing of mouse amygdala after knockdown of miR-15a |
Organism |
Mus musculus |
Experiment type |
Non-coding RNA profiling by high throughput sequencing
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Summary |
MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. We report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex, and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. Here, we performed small RNA Sequencing of mouse basolateral amygdala after miR15a knockdown using injection of a miR-15a sponge virus or control sponge virus.
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Overall design |
Small RNA Sequencing of basolateral amygdala of 5 mice injected with a miR-15a sponge virus and 5 mice injected with a control sponge virus.
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Contributor(s) |
Volk N, Engel M, Binder EB, Chen A |
Citation(s) |
27829158 |
Submission date |
Sep 30, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Mareen Engel |
E-mail(s) |
mareen_engel@psych.mpg.de
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Organization name |
Max-Planck-Institute of Psychiatry
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Department |
Stress Neurobiology and Neurogenetics
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Street address |
Kraepelinstr. 2-10
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City |
Munich |
ZIP/Postal code |
80804 |
Country |
Germany |
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Platforms (1) |
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Samples (10)
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Relations |
BioProject |
PRJNA345045 |
SRA |
SRP090706 |