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| Status |
Public on Aug 15, 2007 |
| Title |
Lymphocyte gene expression data from moderate stage HD patients and controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflammatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared to controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV et al. (2005) Proc Natl Acad Sci U S A 102: 11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies.
Keywords: RNA biomarker screen
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| Overall design |
Lymphocyte samples from 12 moderate stage HD patients (8 female and 4 male) and 10 age-matched controls (5 female and 5 male).
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| Contributor(s) |
Runne H, Kuhn A, Wild EJ, Pratyaksha W, Kristiansen M, Isaacs JD, Régulier E, Delorenzi M, Tabrizi SJ, Luthi-Carter R |
| Citation(s) |
17724341 |
| Submission date |
Aug 13, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Alexandre Kuhn |
| E-mail(s) |
kuhnam@mail.nih.gov
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| Organization name |
NIH
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| Department |
NIA
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| Lab |
Laboratory of Neurogenetics
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| Street address |
35 Convent Dr
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892-3707 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA102041 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8762_RAW.tar |
165.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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