|
| Status |
Public on Sep 15, 2007 |
| Title |
Expression data from hAT1R transgenic and non-transgenic C57BL/6 mouse heart tissue |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Excessive Ang II signaling through AT1R is shown to cause pathological hypertrophy. Underlying molecular mechanisms are not yet known and expression studies are not available so far.
To understand hAT1R signaling, cardiac tissue, from C57BL/6 mouse over expressing hAT1R signaling, is subjected to genomic microarray studies. This data compared with the data from healthy, non transgenic C57BL/6 mouse.
Keywords: disease state analysis
|
| |
|
| Overall design |
Mouse heart tissues are collected from age matched and gender matched samples. RNA is isolated using commercial kits as per the manufacturer's instructions and subjected to quality checks before experiments. cRNA preparation, pre hybridization, hybridization and post hybridization were carried out Genomics core facility, Case western reserve university. 3 chips for each category were taken for present analysis.
|
| |
|
| Contributor(s) |
Kumar VS, Saad Y, Karnik S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 14, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Venkata Suresh Kumar surampudi |
| E-mail(s) |
kumars@ccf.org
|
| Phone |
216-445-6636
|
| Organization name |
Lerner Research Institute
|
| Department |
Molecular Cardiology
|
| Lab |
Karnik Lab
|
| Street address |
9500 Euclid Avenue
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44195 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA102057 |
Less...
More...