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| Status |
Public on Aug 24, 2011 |
| Title |
Dap12-deficient mouse brain (1 month) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is an inherited brain and bone disease. It manifests as dementia and bone fractures. The PLOSL phenotype is caused by loss-of-function mutations in one of the two genes encoding the components of the DAP12/TREM2 receptor complex. The DAP12/TREM2 complex is expressed in cells of the myeloid lineage, including microglia in the central nervous system (CNS). The molecular mechanisms producing the CNS phenotype of PLOSL remain largely unknown. To gain insight into dysfunctional CNS pathways behind PLOSL, we performed genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain. In Dap12-deficient mice, we observed alterations in several pathways involved in synaptic function. In agreement with the myelin loss in PLOSL patients, we also saw changes in transcript levels of genes encoding myelin components.
Keywords: knockout response
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| Overall design |
Transcript profiles of the midbrain (diencephalon and basal ganglia) of three Dap12-knockout and three heterozygous mice were analyzed.
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| Contributor(s) |
Kiialainen A, Linturi H, Saharinen J, Lanier LL, Kopra O, Peltonen L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 17, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Anna Kiialainen |
| E-mail(s) |
Anna.Kiialainen@medsci.uu.se
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| Phone |
+46186114951
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| Organization name |
Uppsala University
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| Department |
Deapartment of Medical Sciences
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| Street address |
University Hospital, Entrance 70
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| City |
Uppsala |
| ZIP/Postal code |
75185 |
| Country |
Sweden |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE9083 |
Genome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain and microglial cells |
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| Relations |
| BioProject |
PRJNA105321 |
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