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| Status |
Public on Dec 23, 2016 |
| Title |
Identify factors associated with preserved hepatic insulin sensitivity despite of hepatic steatosis. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Among all the evaluated factors, only adipose tissue insulin sensitivity (assessed by clamped % suppression of serum free fatty acid), serum concentration of high molecular weight adiponectin, and plasma concentration of TCA cycle metabolites such as citric acid and cis-aconitic acid (assessed by metabolome analysis), associated significantly and positively with hepatic insulin sensitivity in NAFLD.
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| Overall design |
We analyzed the data to identify factors associated with preserved hepatic insulin sensitivity despite of hepatic steatosis. The 26 NAFLD patients with intrahepatic lipid content of >5% were divided into three groups according to the level of hepatic insulin sensitivity, as assessed by clamped % suppression of endogenous glucose production. Then, all the evaluated factors were compared between the hepatic insulin sensitive and resistant patients with comparable hepatic steatosis (n=9 vs 8, respectively).
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| Contributor(s) |
Kumashiro N, Shigiyama F |
| Citation(s) |
29404483 |
| Submission date |
Dec 22, 2016 |
| Last update date |
Feb 01, 2020 |
| Contact name |
Fumika Shigiyama |
| E-mail(s) |
md13019s@oc.toho-u.ac.jp
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| Phone |
819054360570
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| Organization name |
Toho University
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| Department |
Internal Medicine
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| Street address |
6-11-1, Omori Nishi, Otaku
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| City |
Tokyo |
| ZIP/Postal code |
143-8541 |
| Country |
Japan |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA358510 |
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