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| Status |
Public on Jul 01, 2018 |
| Title |
Gene expression of L3 parvalbumin neurons in the DLPFC comparing schizophrenia with unaffected subjects |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Schizophrenia is associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction is manifest as cognitive deficits that appear to arise from disturbances in gamma frequency oscillations.
These oscillations are generated in DLPFC layer 3 via reciprocal connections between pyramidal cells and parvalbumin (PV)-containing interneurons. The density of cortical PV neurons is not altered in schizophrenia, but expression levels of several transcripts involved in PV cell function, including PV, are lower in the disease.
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| Overall design |
We combined a novel immunohistochemical approach, laser microdissection, and microarray profiling to analyze the transcriptome of DLPFC layer 3 PV cells in 36 matched pairs of schizophrenia and unaffected comparison subjects.
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| Contributor(s) |
Enwright JF, Huo Z, Arion D, Corradi JP, Tseng G, Lewis DA |
| Citation(s) |
33328902 |
| Submission date |
Jan 12, 2017 |
| Last update date |
Dec 22, 2020 |
| Contact name |
David Lewis |
| E-mail(s) |
lewisda@upmc.edu
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| Organization name |
University of Pittsburgh
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| Department |
Psychiatry and Neuroscience
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| Street address |
3811 O'Hara St
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| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
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| Samples (141)
|
| GSM2455099 |
pair 1, diagnosis Control, replicate 2 |
| GSM2455100 |
pair 1, diagnosis Control, replicate 1 |
| GSM2455101 |
pair 10, diagnosis Control, replicate 1 |
| GSM2455102 |
pair 10, diagnosis Control, replicate 2 |
| GSM2455103 |
pair 11, diagnosis Control, replicate 1 |
| GSM2455104 |
pair 11, diagnosis Control, replicate 2 |
| GSM2455105 |
pair 12, diagnosis Control, replicate 2 |
| GSM2455106 |
pair 12, diagnosis Control, replicate 1 |
| GSM2455107 |
pair 13, diagnosis Control, replicate 1 |
| GSM2455108 |
pair 13, diagnosis Control, replicate 2 |
| GSM2455109 |
pair 14, diagnosis Control, replicate 2 |
| GSM2455110 |
pair 14, diagnosis Control, replicate 1 |
| GSM2455111 |
pair 15, diagnosis Control, replicate 2 |
| GSM2455112 |
pair 15, diagnosis Control, replicate 1 |
| GSM2455113 |
pair 16, diagnosis Control, replicate 1 |
| GSM2455114 |
pair 16, diagnosis Control, replicate 2 |
| GSM2455115 |
pair 17, diagnosis Control, replicate 2 |
| GSM2455116 |
pair 17, diagnosis Control, replicate 1 |
| GSM2455117 |
pair 18, diagnosis Control, replicate 1 |
| GSM2455118 |
pair 18, diagnosis Control, replicate 2 |
| GSM2455119 |
pair 19, diagnosis Control, replicate 2 |
| GSM2455120 |
pair 19, diagnosis Control, replicate 1 |
| GSM2455121 |
pair 2, diagnosis Control, replicate 2 |
| GSM2455122 |
pair 2, diagnosis Control, replicate 1 |
| GSM2455123 |
pair 3, diagnosis Control, replicate 2 |
| GSM2455124 |
pair 3, diagnosis Control, replicate 1 |
| GSM2455125 |
pair 4, diagnosis Control, replicate 1 |
| GSM2455126 |
pair 4, diagnosis Control, replicate 2 |
| GSM2455127 |
pair 5, diagnosis Control, replicate 1 |
| GSM2455128 |
pair 5, diagnosis Control, replicate 2 |
| GSM2455129 |
pair 6, diagnosis Control, replicate 2 |
| GSM2455130 |
pair 6, diagnosis Control, replicate 1 |
| GSM2455131 |
pair 7, diagnosis Control, replicate 2 |
| GSM2455132 |
pair 7, diagnosis Control, replicate 1 |
| GSM2455133 |
pair 8, diagnosis Control, replicate 1 |
| GSM2455134 |
pair 8, diagnosis Control, replicate 2 |
| GSM2455135 |
pair 9, diagnosis Control, replicate 2 |
| GSM2455136 |
pair 9, diagnosis Control, replicate 1 |
| GSM2455137 |
pair 20, diagnosis Control, replicate 2 |
| GSM2455138 |
pair 20, diagnosis Control, replicate 1 |
| GSM2455139 |
pair 29, diagnosis Control, replicate 1 |
| GSM2455140 |
pair 29, diagnosis Control, replicate 2 |
| GSM2455141 |
pair 30, diagnosis Control, replicate 1 |
| GSM2455142 |
pair 30, diagnosis Control, replicate 2 |
| GSM2455143 |
pair 31, diagnosis Control, replicate 2 |
| GSM2455144 |
pair 31, diagnosis Control, replicate 1 |
| GSM2455145 |
pair 32, diagnosis Control, replicate 2 |
| GSM2455146 |
pair 32, diagnosis Control, replicate 1 |
| GSM2455147 |
pair 33, diagnosis Control, replicate 1 |
| GSM2455148 |
pair 33, diagnosis Control, replicate 2 |
| GSM2455149 |
pair 34, diagnosis Control, replicate 1 |
| GSM2455150 |
pair 35, diagnosis Control, replicate 1 |
| GSM2455151 |
pair 35, diagnosis Control, replicate 2 |
| GSM2455152 |
pair 36, diagnosis Control, replicate 2 |
| GSM2455153 |
pair 36, diagnosis Control, replicate 1 |
| GSM2455154 |
pair 21, diagnosis Control, replicate 1 |
| GSM2455155 |
pair 21, diagnosis Control, replicate 2 |
| GSM2455156 |
pair 22, diagnosis Control, replicate 1 |
| GSM2455157 |
pair 22, diagnosis Control, replicate 2 |
| GSM2455158 |
pair 23, diagnosis Control, replicate 1 |
| GSM2455159 |
pair 23, diagnosis Control, replicate 2 |
| GSM2455160 |
pair 24, diagnosis Control, replicate 2 |
| GSM2455161 |
pair 24, diagnosis Control, replicate 1 |
| GSM2455162 |
pair 25, diagnosis Control, replicate 1 |
| GSM2455163 |
pair 25, diagnosis Control, replicate 2 |
| GSM2455164 |
pair 26, diagnosis Control, replicate 2 |
| GSM2455165 |
pair 26, diagnosis Control, replicate 1 |
| GSM2455166 |
pair 27, diagnosis Control, replicate 1 |
| GSM2455167 |
pair 27, diagnosis Control, replicate 2 |
| GSM2455168 |
pair 28, diagnosis Control, replicate 2 |
| GSM2455169 |
pair 28, diagnosis Control, replicate 1 |
| GSM2455170 |
pair 1, diagnosis Schiz, replicate 1 |
| GSM2455171 |
pair 1, diagnosis Schiz, replicate 2 |
| GSM2455172 |
pair 10, diagnosis Schiz, replicate 2 |
| GSM2455173 |
pair 10, diagnosis Schiz, replicate 1 |
| GSM2455174 |
pair 11, diagnosis Schiz, replicate 2 |
| GSM2455175 |
pair 11, diagnosis Schiz, replicate 1 |
| GSM2455176 |
pair 12, diagnosis Schiz, replicate 2 |
| GSM2455177 |
pair 12, diagnosis Schiz, replicate 1 |
| GSM2455178 |
pair 13, diagnosis Schiz, replicate 1 |
| GSM2455179 |
pair 13, diagnosis Schiz, replicate 2 |
| GSM2455180 |
pair 14, diagnosis Schiz, replicate 1 |
| GSM2455181 |
pair 14, diagnosis Schiz, replicate 2 |
| GSM2455182 |
pair 15, diagnosis Schiz, replicate 1 |
| GSM2455183 |
pair 15, diagnosis Schiz, replicate 2 |
| GSM2455184 |
pair 16, diagnosis Schiz, replicate 2 |
| GSM2455185 |
pair 16, diagnosis Schiz, replicate 1 |
| GSM2455186 |
pair 17, diagnosis Schiz, replicate 2 |
| GSM2455187 |
pair 17, diagnosis Schiz, replicate 1 |
| GSM2455188 |
pair 18, diagnosis Schiz, replicate 2 |
| GSM2455189 |
pair 18, diagnosis Schiz, replicate 1 |
| GSM2455190 |
pair 19, diagnosis Schiz, replicate 2 |
| GSM2455191 |
pair 19, diagnosis Schiz, replicate 1 |
| GSM2455192 |
pair 2, diagnosis Schiz, replicate 1 |
| GSM2455193 |
pair 2, diagnosis Schiz, replicate 2 |
| GSM2455194 |
pair 3, diagnosis Schiz, replicate 1 |
| GSM2455195 |
pair 3, diagnosis Schiz, replicate 2 |
| GSM2455196 |
pair 4, diagnosis Schiz, replicate 1 |
| GSM2455197 |
pair 4, diagnosis Schiz, replicate 2 |
| GSM2455198 |
pair 5, diagnosis Schiz, replicate 1 |
| GSM2455199 |
pair 5, diagnosis Schiz, replicate 2 |
| GSM2455200 |
pair 6, diagnosis Schiz, replicate 2 |
| GSM2455201 |
pair 6, diagnosis Schiz, replicate 1 |
| GSM2455202 |
pair 7, diagnosis Schiz, replicate 1 |
| GSM2455203 |
pair 7, diagnosis Schiz, replicate 2 |
| GSM2455204 |
pair 8, diagnosis Schiz, replicate 2 |
| GSM2455205 |
pair 8, diagnosis Schiz, replicate 1 |
| GSM2455206 |
pair 9, diagnosis Schiz, replicate 2 |
| GSM2455207 |
pair 9, diagnosis Schiz, replicate 1 |
| GSM2455208 |
pair 20, diagnosis Schiz, replicate 1 |
| GSM2455209 |
pair 20, diagnosis Schiz, replicate 2 |
| GSM2455210 |
pair 29, diagnosis Schiz, replicate 2 |
| GSM2455211 |
pair 29, diagnosis Schiz, replicate 1 |
| GSM2455212 |
pair 30, diagnosis Schiz, replicate 2 |
| GSM2455213 |
pair 31, diagnosis Schiz, replicate 2 |
| GSM2455214 |
pair 31, diagnosis Schiz, replicate 1 |
| GSM2455215 |
pair 32, diagnosis Schiz, replicate 2 |
| GSM2455216 |
pair 32, diagnosis Schiz, replicate 1 |
| GSM2455217 |
pair 33, diagnosis Schiz, replicate 2 |
| GSM2455218 |
pair 33, diagnosis Schiz, replicate 1 |
| GSM2455219 |
pair 34, diagnosis Schiz, replicate 1 |
| GSM2455220 |
pair 34, diagnosis Schiz, replicate 2 |
| GSM2455221 |
pair 35, diagnosis Schiz, replicate 1 |
| GSM2455222 |
pair 35, diagnosis Schiz, replicate 2 |
| GSM2455223 |
pair 36, diagnosis Schiz, replicate 2 |
| GSM2455224 |
pair 36, diagnosis Schiz, replicate 1 |
| GSM2455225 |
pair 21, diagnosis Schiz, replicate 1 |
| GSM2455226 |
pair 21, diagnosis Schiz, replicate 2 |
| GSM2455227 |
pair 22, diagnosis Schiz, replicate 2 |
| GSM2455228 |
pair 22, diagnosis Schiz, replicate 1 |
| GSM2455229 |
pair 23, diagnosis Schiz, replicate 2 |
| GSM2455230 |
pair 23, diagnosis Schiz, replicate 1 |
| GSM2455231 |
pair 24, diagnosis Schiz, replicate 2 |
| GSM2455232 |
pair 24, diagnosis Schiz, replicate 1 |
| GSM2455233 |
pair 25, diagnosis Schiz, replicate 2 |
| GSM2455234 |
pair 25, diagnosis Schiz, replicate 1 |
| GSM2455235 |
pair 26, diagnosis Schiz, replicate 1 |
| GSM2455236 |
pair 27, diagnosis Schiz, replicate 1 |
| GSM2455237 |
pair 27, diagnosis Schiz, replicate 2 |
| GSM2455238 |
pair 28, diagnosis Schiz, replicate 2 |
| GSM2455239 |
pair 28, diagnosis Schiz, replicate 1 |
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| Relations |
| BioProject |
PRJNA361167 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE93577_RAW.tar |
462.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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