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| Status |
Public on Feb 18, 2018 |
| Title |
Transcriptome profiles of liver biopsy tissues from sever alcoholic hepatitis patients (derivation cohort) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Corticosteroids are the current standard of care to improve short-term mortality in severe alcoholic hepatitis (AH), although nearly 40% of the patients do not respond and accurate pre-treatment predictors are lacking. We developed 123-gene prognostic score based on molecular and clinical variables before initiation of corticosteroids. Furthermore, The gene signature was implemented in an FDA-approved platform (NanoString), and verified for technical validity and prognostic capability. Here we demonstrated that a Nanostring-based gene expressoin risk classificatoin is useful to predict mortality in patients with severe alcoholic hepatitis who were treated by corticosteroid
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| |
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| Overall design |
Gene expression profiling of formalin-fixed paraffin-embedded liver biopsy tissues obtained at the time of enrollment.
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| |
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| Contributor(s) |
Trépo E, Goossens N, Fujiwara N, Hoshida Y, Franchimont D |
| Citation(s) |
29158192 |
| Submission date |
Feb 01, 2017 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Yujin Hoshida |
| E-mail(s) |
Yujin.Hoshida@UTSouthwestern.edu
|
| Organization name |
University of Texas Southwestern Medical Center
|
| Street address |
5323 Harry Hines Blvd
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
|
| Samples (71)
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| This SubSeries is part of SuperSeries: |
| GSE94417 |
An integrative transcriptomic and clinical score for mortality prediction in severe alcoholic hepatitis treated with corticosteroids |
|
| Relations |
| BioProject |
PRJNA369562 |
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