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| Status |
Public on Mar 01, 2018 |
| Title |
Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Placebo Controlled Pilot Trial |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Changes in gene expression were consistent with mechanism of action and show that clinical response to treatment with belimumab is associated with significant decrease in profibrotic genes and pathways. Additional study is needed to determine the role of belimumab in the treatment of dcSSc
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| |
|
| Overall design |
To assess the safety and efficacy of treatment with belimumab in patients with early diffuse cutaneous systemic sclerosis (dcSSc) treated with background mycophenolate mofetil (MMF).
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| |
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| Contributor(s) |
Gordon JK, Martyanov V, Franks J, Bernstein EJ, Szymonifka J, Magro C, Wildman HF, Wood TA, Whitfield ML, Spiera RF |
| Citation(s) |
29073351 |
| Submission date |
Mar 30, 2017 |
| Last update date |
May 31, 2018 |
| Contact name |
Tammara Wood |
| E-mail(s) |
tammara.a.wood@dartmouth.edu
|
| Organization name |
Dartmouth Medical School
|
| Department |
Biomedical Data Science
|
| Lab |
Whitfield Lab
|
| Street address |
WTRB 674
|
| City |
Lebanon |
| State/province |
NH |
| ZIP/Postal code |
03756 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
|
| Samples (36)
|
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| Relations |
| BioProject |
PRJNA381074 |
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