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| Status |
Public on Feb 14, 2018 |
| Title |
Modeling the pathogenesis of Charcot-Marie-Tooth disease type 1A using patient-specific iPSCs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here, human induced pluripotent stem cells (control-hiPSCs, CMT1A-hiPSCs, and PMP22-hiPSCs) were induced to differentiate to Schwann cells (control-SCs, CMT1A-SCs, and PMP22-SCs) through neural crest stage (control-NCSCs, CMT1A-NCSCs, and PMP22-NCSCs). We sequenced mRNA samples from Schwann cell differentiation of human pluripotent stem cells at 3 different stage to generate the gene expression profiles of these cells.
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| Overall design |
7 samples, including undifferentiated hiPSCs (control-hiPSCs and CMT1A-hiPSCs), freshly isolated p75+/HNK1+ NCSCs (control-NCSCs and CMT1A-NCSCs), and SCs (control-SCs, CMT1A-SCs, and PMP22-SCs) were analyzed.
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| Contributor(s) |
Li W, Huang L, Xiang AP |
| Citation(s) |
29276154 |
| Submission date |
Apr 16, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Weiqiang Li |
| E-mail(s) |
liweiq6@mail.sysu.edu.cn
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| Organization name |
Sun Yat-sen university
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| Street address |
Zhongshan Road 2
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| City |
Guangzhou |
| ZIP/Postal code |
510080 |
| Country |
China |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA383068 |
| SRA |
SRP104118 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE97851_RNA-seq_data_of_SCs.xlsx |
2.3 Mb |
(ftp)(http) |
XLSX |
| GSE97851_RNA-seq_data_of_hiPSCs_and_NCSCs.xlsx |
1.9 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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