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Series GSE99159 Query DataSets for GSE99159
Status Public on Feb 21, 2018
Title Tcf-1 shapes the chromatin landscape of naive T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary We investigate the requirement of the transcription factor Tcf-1 for T cell specific accessible elements and gene expression in developing T cells. We examine the impact of Tcf-1 on creating chromatin accessibility related to T cell identity in an unrelated, differentiated cell-type.
 
Overall design Examination of chromatin accessibility in developing DP T cells from WT and Tcf-1 KO. Examination of chromatin accessibility, repressive histone modifications, and binding of Tcf-1 after ectopic expression in NIH3T3 fibroblasts.
 
Contributor(s) Johnson JL, Georgakilas G
Citation(s) 29466756
Submission date May 22, 2017
Last update date Jul 25, 2021
Contact name Herbert R De'Broski
E-mail(s) debroski@vet.upenn.edu
Organization name University of Pennsylvania
Street address 3800 Spruce St
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL21626 NextSeq 550 (Mus musculus)
Samples (321)
GSM2634330 DP ATAC-seq Rep 1
GSM2634331 DP ATAC-seq Rep 2
GSM2634332 Tcf-1 KO DP ATAC-seq Rep 1
Relations
BioProject PRJNA387446
SRA SRP107772

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99159_RAW.tar 11.3 Gb (http)(custom) TAR (of BED, BW)
GSE99159_mTCF1_CST2206S_Day2_NIH3T3_Merged.Overlap.With.IDR.0.02.Summits.bed.gz 566.1 Kb (ftp)(http) BED
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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