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| Status |
Public on Feb 22, 2018 |
| Title |
KH-type splicing regulatory protein (KHSRP) is involved in esophageal squamous cell carcinoma progression through regulating a subset of microRNAs [mRNA] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein (RBP), which is involved in many post-transcriptional aspects of RNA metabolism including microRNA (miRNA) biogenesis, affects distinct cell functions in different tissues and can impact on various pathological conditions. However, the function and underlying mechanisms of KHSRP in esophageal squamous cell carcinoma (ESCC) remain largely unknown. In the present study, we uncover a novel oncogenic function of KHSRP in esophageal tumorigenesis, and implicate its use as a marker for prognostic evaluation and as a putative therapeutic target in ESCC.
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| Overall design |
To investigate the molecular pathways involved by KHSRP-knockdown, the expression levels of mRNAs in KHSRP-knockdown cells were analyzed using microarray.
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| Contributor(s) |
Fujita Y, Masuda K, Imoto I |
| Citation(s) |
29254151 |
| Submission date |
May 30, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Kiyoshi Masuda |
| E-mail(s) |
kiyoshim@tokushima-u.ac.jp
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| Organization name |
Institute of Biomedical Sciences, Tokushima University Graduate School
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| Department |
Department of Human Genetics
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| Street address |
3-18-15 Kuramoto-cho
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| City |
Tokushima |
| ZIP/Postal code |
770-8503 |
| Country |
Japan |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE99424 |
KH-type splicing regulatory protein (KHSRP) is involved in esophageal squamous cell carcinoma progression through regulating a subset of microRNAs |
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| Relations |
| BioProject |
PRJNA388433 |
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