GEO DataSets

(Submitter supplied) We identify the tetraspanin CD82 as the recognition site for xenogeneic endothelial cells independently of Gala1,3-gal structures. We demonstrate that in contrast to undifferentiated cells, differentiated promyelocytic cell lines (HL-60, THP-1 and KG-1) are capable of recognizing xenogeneic porcine endothelial cells in a calcium-dependent manner. We used serial analysis of gene expression (SAGE) to identify the differentially expressed transcripts in these cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

5 Samples

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(Submitter supplied) Background: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. Methods: We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC in vivo using replicate LongSAGE libraries. We refer to these libraries as the LNCaP atlas and compared these gene expression profiles with current suggested models of CRPC. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

9 Samples

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(Submitter supplied) A plethora of research has focused on the human embryonic stem cells (hESC) ever since they were first reported mainly due to their distinct features of self renewal and pluripotency. Probing of the hESC transcriptome using global expression profiling tools such as DNA microarray, Serial Analysis of Gene Expression (SAGE), Massively Parallel Signature Sequencing (MPSS) and Expressed Sequence Tag (EST) analysis have contributed significantly in our current understanding of hESCs. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

2 Samples

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(Submitter supplied) Mantle cell lymphoma is characterized by a t(11;14) chromosomal translocation; however, it alone is insufficient to result in the disease. A number of secondary genetic alterations have been proposed as essential in MCL pathogenesis. Amongst these, numerous copy number altered regions remain ill-defined, both for location and prognostic significance. In this study we examined in detail the genomes of a panel of 52 MCL cases. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE; Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL2616 GPL4544 GPL1485

57 Samples

Download data: TXT

(Submitter supplied) Background: The development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using long serial analysis of gene expression (LongSAGE) libraries. Results: There were 131 tags (87 genes) that displayed statistically significant (p=<0.001) differences in expression in response to androgen. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

2 Samples

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(Submitter supplied) This series represents the Cancer Genome Anatomy Project SAGE library collection. Libraries contained herein were either produced through CGAP funding, or donated to CGAP. The Cancer Genome Anatomy Project (CGAP: http://cgap.nci.nih.gov) is an interdisciplinary program established and administered by the National Cancer Institute (NCI: http://www.nci.nih.gov) to generate the information and technological tools needed to decipher the molecular anatomy of the cancer cell. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

36 Samples

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(Submitter supplied) To identify new candidate genes for neurocristopathies, a Long-SAGE library has been made from human neural crest cells (hNCC) derived from a normal embryo at Carnegie stage 13. Data analysis indicates the expression of a number of genes in multiple GO functional classes that were anticipated based on animal studies and/or human disease. An average linkage hierarchical clustering was performed using SAGE data from hNCC and 14 other normal tissues and cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

1 Sample

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(Submitter supplied) Human embryonic stem cells (hESCs) offer an important model for investigating the human hematopoietic celldevelopment. Here, we used long serial analysis of gene expression and quantitative real-time PCR to characterize two subsets of primitive hematopoietic cells derived in vitro from hESCs. This revealed differences in their expression of genes associated with lymphoid and myeloid development, cellular biosynthetic processes, and cell cycle regulation. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

6 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by SAGE

Platforms:

GPL1485 GPL1352

16 Samples

Download data: CEL

(Submitter supplied) Highly purified subpopulations of primitive bipotent and committed luminal progenitor cells as well as mature luminal and myoepithelial cells from normal human mammary tissue were isolated and compared their transcriptomes which were obtained using PCR-Long-SAGE technology. Keywords: mammary progenitors, stem cells, Notch signaling, gene expression

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

4 Samples

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(Submitter supplied) 16 Long SAGE libraries Keywords: Various degrees of cervical dysplasia

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

16 Samples

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(Submitter supplied) In this study, we sequenced 691,390 SAGE tags from four libraries. Cervical L-SAGE libraries N1, N2, C1, and C2 were sequenced to 165,624, 181,224, 173,534, and 171,008 tags, respectively. Duplicate ditags were eliminated from analysis resulting in 136,276, 139,656, 154,828 and 136,386 useful tags respectively and a total of 24 058 unique tags. 15,438 of the unique tags mapped to annotated UniGene identifiers. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

4 Samples

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(Submitter supplied) Glomeruli were isolated from the kidney of a 72 yo male patient. The kidney was surgically removed due to renal cell carcinoma. The glomeruli were isolated from uninvolved renal parenchyma. Histology (H&E) of glomeruli and interstitium was normal. Keywords: Kidney Subcompartment

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

1 Sample

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(Submitter supplied) APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from those of APOE3/3 AD patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platforms:

GPL4 GPL1485

6 Samples

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(Submitter supplied) Identifying the chromosomal targets of transcription factors is important for reconstructing the transcriptional regulatory networks underlying global gene expression programs. We have developed an unbiased genomic method called sequence tag analysis of genomic enrichment (STAGE) to identify the direct binding targets of transcription factors in vivo. STAGE is based on high-throughput sequencing of concatemerized tags derived from target DNA enriched by chromatin immunoprecipitation. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL1485

2 Samples

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(Submitter supplied) This series represents the Cancer Genome Anatomy Project SAGE library collection. Libraries contained herein were either produced through CGAP funding, or donated to CGAP. The Cancer Genome Anatomy Project (CGAP: http://cgap.nci.nih.gov) is an interdisciplinary program established and administered by the National Cancer Institute (NCI: http://www.nci.nih.gov) to generate the information and technological tools needed to decipher the molecular anatomy of the cancer cell. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL1485

88 Samples

Download data

(Submitter supplied) This series represents the Cancer Genome Anatomy Project SAGE library collection. Libraries contained herein were either produced through CGAP funding, or donated to CGAP. The Cancer Genome Anatomy Project (CGAP: http://cgap.nci.nih.gov) is an interdisciplinary program established and administered by the National Cancer Institute (NCI: http://www.nci.nih.gov) to generate the information and technological tools needed to decipher the molecular anatomy of the cancer cell. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by SAGE

4 related Platforms

765 Samples

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(Submitter supplied) This is a virtual platform for longSAGE 17 libraries generated for Homo sapiens using NlaIII as an anchor enzyme. Platform_anchor: NlaIII

Organism:

Homo sapiens

17 Series

177 Samples

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