GEO DataSets

(Submitter supplied) Naturally occurring canine invasive urinary carcinoma (iUC) closely resembles human muscle invasive bladder cancer in terms of histopathology, metastases, response to therapy and, low survival rate. The heterogeneous nature of the disease has led to the association of large numbers of risk loci in humans, however most are of small effect. There exists a need for new and accurate animal models of invasive bladder cancer. more...

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

160 Samples

Download data: IDAT, TXT

(Submitter supplied) The 1986 Chernobyl nuclear disaster initiated a series of catastrophic events resulting in long-term and widespread environmental contamination. We characterize the genetic structure of 302 dogs representing three free-roaming dog populations living within the power plant itself, or 15-45 km from the disaster site. Genome-wide profiles from Chernobyl, purebred, and free-breeding dogs world-wide reveal that the individuals from the power plant and Chernobyl City are genetically distinct, with the former displaying increased intrapopulation genetic similarity and differentiation. more...

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array

Platform:

GPL17481

299 Samples

Download data: BED, BIM, FAM, IDAT, TXT

(Submitter supplied) Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing an innovative framework for understanding relationships between breeds and the behaviors that define them utilizing genetic data for over 4,000 domestic, semi-feral and wild canids and behavioral survey data for over 46,000 dogs. more...

Organism:

Canis lupus dingo; Canis lupus familiaris; Canis lupus

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL17481

956 Samples

Download data: IDAT, TXT

(Submitter supplied) Comparison of SNP profiles of the Patagonain Sheepdog with European breeds confirms Scottish origin and position basal to modern herding breeds.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL17481

146 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

Genome binding/occupancy profiling by high throughput sequencing; SNP genotyping by SNP array

Platforms:

GPL17481 GPL28490

335 Samples

Download data: IDAT, NARROWPEAK

(Submitter supplied) Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in dogs

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

311 Samples

Download data: IDAT, TXT

(Submitter supplied) Canine gastric dilatation-volvulus (GDV) is a common life-threatening condition occurring primarily in large and giant breeds with a 3.9% to 36.7% lifetime risk. GDV is a complex disease with risk factors including age, diet, behavior, family history, and genetics. The genetic correlates of GDV have not previously been systematically explored. We undertook multiplatform genome-wide association analysis (GWAS) of 253 dogs including 106 healthy dogs and 147 dogs with at least one GDV episode. more...

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL17481

215 Samples

Download data: IDAT, TXT

(Submitter supplied) Allele frequency analysis reveals that the breed is enhanced for genes controlling traits associated with the poodle-type coat, which are perceived to have an association with hypoallergenicity, with no strong signatures of selection for Labrador retriever (LAB) traits. This study provides a blueprint for understanding how dog breeds are formed, highlighting the limited scope of trait selection in defining seemingly new breeds.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

47 Samples

Download data: IDAT, TXT

(Submitter supplied) SNP genotyping was used to determine if the free living Highland Wild dogs of Papua, Indonesia are the ansestors of captive New Guinea Singing Dogs.

Organism:

Canis lupus familiaris; Canis lupus

Type:

SNP genotyping by SNP array

Platform:

GPL17481

14 Samples

Download data: IDAT, TXT

(Submitter supplied) SNP of new dog breeds improves the validity of population clustering and breed based phylogenies.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL17481

95 Samples

Download data: IDAT, TXT

(Submitter supplied) Through thousands of years of breeding and strong human selection, the dog (Canis lupus familiaris) exists today within hundreds of closed populations throughout the world, each with defined phenotypes. A singular geographic region with broad diversity in dog breeds presents an interesting opportunity to observe potential mechanisms of breed formation. Italy claims 14 internationally recognized dog breeds, with numerous additional local varieties. more...

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

273 Samples

Download data: IDAT, TXT

(Submitter supplied) Background: Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex developmental malformation of the skull and craniocervical vertebrae called Chiari-like malformation (CM) characterized by a conformational change and overcrowding of the brain and cervical spinal cord particularly at the craniocervical junction. more...

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

96 Samples

Download data: JPG, TXT

(Submitter supplied) Analysis of genotypes at 150,000 SNPs reveals patterns of allele and haplotype sharing that describes the breed relationships and development of 161 breeds of dog.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array

Platform:

GPL17481

158 Samples

Download data: IDAT, TXT

(Submitter supplied) Building demographic profiles in domestic dog breeds to optimize genetic trait mapping study design

Organism:

Canis lupus; Canis lupus familiaris

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platform:

GPL17481

795 Samples

Download data: IDAT, TXT

(Submitter supplied) The Italian island of Sardinia is well known in studies of human population isolates. It is also home to the Fonni's Dog, a breed of canine whose development was reliant on the functionality of the dog. Using genome-wide variant and sequence analyses, we have characterized the Fonni's Dog relative to 27 other dog breeds from the Mediterranean region. We determine introgression events relevant to Mediterranean breed development and describe how the Fonni's dog presents an intriguing model demonstrating the characteristics of traditional human population isolates and, in particular, exhibiting the unique demographic composition of the people of Sardinia.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

4 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

137 Samples

Download data: IDAT

(Submitter supplied) The Italian island of Sardinia is well known in studies of human population isolates. It is also home to the Fonni's Dog, a breed of canine whose development was reliant on the functionality of the dog. Using genome-wide variant and sequence analyses, we have characterized the Fonni's Dog relative to 27 other dog breeds from the Mediterranean region. We determine introgression events relevant to Mediterranean breed development and describe how the Fonni's dog presents an intriguing model demonstrating the characteristics of traditional human population isolates and, in particular, exhibiting the unique demographic composition of the people of Sardinia.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

82 Samples

Download data: IDAT, TXT

(Submitter supplied) The Italian island of Sardinia is well known in studies of human population isolates. It is also home to the Fonni's Dog, a breed of canine whose development was reliant on the functionality of the dog. Using genome-wide variant and sequence analyses, we have characterized the Fonni's Dog relative to 27 other dog breeds from the Mediterranean region. We determine introgression events relevant to Mediterranean breed development and describe how the Fonni's dog presents an intriguing model demonstrating the characteristics of traditional human population isolates and, in particular, exhibiting the unique demographic composition of the people of Sardinia.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL17481

51 Samples

Download data: IDAT, TXT

(Submitter supplied) Degenerative myelopathy (DM) is a canine disease very similar to amyotrophic lateral sclerosis (ALS) in humans. We previously showed that DM is a promising model for ALS, as genome-wide association identified a mutation in SOD1, a known ALS gene. In this study, we identify a modifier gene, SP110, which strongly affects overall disease risk and age-of-onset in Pembroke Welsh corgis at risk of DM. Dissecting the complex genetics of this disease in a model organism may lead to new insights about risk and progression in both canine and human patients.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

46 Samples

Download data: TXT

(Submitter supplied) Degenerative myelopathy (DM) is a canine disease very similar to amyotrophic lateral sclerosis (ALS) in humans. We previously showed that DM is a promising model for ALS, as genome-wide association identified a mutation in SOD1, a known ALS gene. In this study, we identify a modifier gene, SP110, which strongly affects overall disease risk and age-of-onset in Pembroke Welsh corgis at risk of DM. Dissecting the complex genetics of this disease in a model organism may lead to new insights about risk and progression in both canine and human patients.

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL17481

25 Samples

Download data: TXT