GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL24247 GPL25266

20 Samples

Download data: RCC, TXT

(Submitter supplied) Dysregulation of mast cell activation can lead to allergic and anaphylactic reactions. Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins (RBPs) is critical in controlling immune cell responses, including mast cell functionality. The Regnase family of RBPs plays a central role in regulating gene expression and controlling immune responses in both lymphoid and myeloid cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

12 Samples

Download data: RCC, TXT

(Submitter supplied) Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality. We previously established that CDI in mice did not protect against reinfection and was associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem. Herein, we demonstrate that the secreted toxin TcdB2 is responsible for subversion of Bmem responses. TcdB2 from an endemic C. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL25266

12 Samples

Download data: RCC, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL19964 GPL25266

24 Samples

Download data: RCC

(Submitter supplied) WT or KO mice were subctaneously injected with 500 L3 larvae or saline and euthanized after 7 days. The lungs were excised and digested to generate a single cells suspension, from whichCD11c+ cells were bead-enriched for gene expression analysis. Cell lysates were used directly with the hybridization probes using the manufacterers protocol (Nanostring).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

6 Samples

Download data: RCC, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL21103 GPL25266 GPL24247

52 Samples

Download data: RCC, TXT

(Submitter supplied) Due to the limited efficacy of Immune checkpoint blockade (ICB) in mammary solid tumors alternative strategies are required. We demonstrated that cholesterol homeostasis plays a significant role in myeloid immune function and breast cancer progression. In this study, we focus on NR0B2. We conducted both in vitro and in vivo studies along with developing a small molecule agonist. NR0B2 functions within myeloid immune cells as a regulator of the NLRP3 inflammasome, which further facilitates T cell differentiation away from immune-suppressive regulatory T cells (Treg). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

8 Samples

Download data: RCC

(Submitter supplied) Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1. Murine studies indicated a specific role of the XCR1-XCL1 axis in the induction of immune responses. Here, we describe that human cDC1 can be distinguished into XCR1- and XCR1+ cDC1 in lymphoid as well as non-lymphoid tissues. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

8 Samples

Download data: RCC, TXT

(Submitter supplied) High-dimensional approaches have revealed emerging heterogeneity within dendritic cells (DC), including a population of transitional DC (tDC) present in mouse and human. However, tDC origin and relationship to other DC subsets are not fully understood because their phenotype partially overlaps with previous definitions of conventional DC precursors (pre-cDC). Here, we show that tDC are distinct from other well-characterized DC and pre-cDC. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

12 Samples

Download data: RCC

(Submitter supplied) The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the negative outcome of non-conformal radiotherapy (RT). However, non-conformal RT is irrelevant in the clinic, and little is known about the role of monocytes following radiotherapy modes used in patients, such as conformal radiotherapy (CRT). Here, we investigated the acute immune infiltration post-CRT. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL25266

12 Samples

Download data: RCC

(Submitter supplied) Mastitis is one of the most prevalent and economically important diseases of dairy animals. The disease is caused by ascending bacterial infection through the teat canal. Among the most common mastitis-causing bacteria are gram-negative coliforms, gram-positive streptococci and staphylococci, and mycoplasma. The most prominent cellular hallmark of acute mammary infection is a massive recruitment of blood neutrophils into the tubular and alveolar milk spaces. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

12 Samples

Download data: XLSX

(Submitter supplied) Erythropoietin (EPO) has multiple functions beyond stimulating erythrocytosis, including modulation of T cell immunity. Effects EPO in transplantation and associated mechanisms remain incompletely understood. We analyzed outcomes and performed cellular and molecular mechanistic assessments in murine wild type (WT) and conditional EPO receptor (EPOR) knockout recipients of cardiac allografts. In translational studies, we tested EPO’s effects in a non-human primate system.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

16 Samples

Download data: RCC

(Submitter supplied) Heligmosomoides polygyrus larvae induce a strong intestinal granuloma response within their murine host, which has been associated with resistance. Immune cells, mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites to immobilize and damage/kill developing worms. In a one dose (bolus) experimental infection, infected C57Bl/6 mice are unable to clear parasites which results in chronic infection with high worm burdens. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL25266

15 Samples

Download data: RCC

(Submitter supplied) Targeted gene expression on Lewis lung carcinoma (LLC) sorted MHC-IIlow macrophages (M2), Ly6Chigh inflammatory (IM) and Ly6Clow residential (RM) monocytes to investigate the effect of anti-PD-L1 mAb on specific myeloid subsets in the lung tumor microenvironment performed using the nCounter Myeloid Innate Immunity Panel by Nanostring .

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

20 Samples

Download data: RCC

(Submitter supplied) Radiation and BCG instillations are used clinically for treatment of urothelial carcinoma, but the precise mechanisms by which they activate an immune response remain elusive. The role of the cGAS-STING pathway has been implicated in both BCG and radiation-induced immune response however comparison of STING-pathway molecules and immune landscape following treatment in urothelial carcinoma has not be performed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

23 Samples

Download data: RCC

(Submitter supplied) Lacrimal gland secretory dysfunction in Sjögren syndrome (SS) causes ocular surface desiccation that is associated with increased cytokine expression and number of antigen-presenting cells (APCs) in the conjunctiva. This study evaluated the hypothesis that desiccating stress (DS) alters the percentage and gene expression of myeloid cell populations in the conjunctiva.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

8 Samples

Download data: RCC

(Submitter supplied) Resident macrophages from naïve mice or resident/inflammatory macrophages from mice treated with zymosan(10ug) 3 days prior were purified from C57BL/6 CD45.2+ donor mice. Purified populations were transferred into mirroring CD45.1/2+ recipient mice or clodronate pre-treated recipient mice. Donor populations were purified 8 weeks following transfer for Nanostring analysis.

Organism:

Mus musculus

Type:

Other

Platform:

GPL25266

23 Samples

Download data: RCC

(Submitter supplied) The activity of bone marrow hematopoeitic cells is tightly controlled by neurogenic innervations. As bone marrow cells mainly receive innervation from beta-3 adrenergic receptor, here we investigated the impact of beta3-adrenergic innervation on bone marrow cell transcriptome alterations. We sorted hematopoetic stem cells (HSCs) from wild type mice (control group) or Adrb3-/- mice (devoid of beta3-adrenergic receptor). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

12 Samples

Download data: RCC

(Submitter supplied) Conventional dendritic cells (cDCs) in the lung drive effector T cell differentiation, and initiate allergic responses upon inhalation of allergens. However, CD11b+ cDCs are composed Ly-6C+ and Ly-6C– subpopulations, and the specific function of each subpopulation has been elusive. Since Ly-6C+ CD11b+ cDCs lost the surface display of Ly-6C upon ex vivo culture, we hypothesized that Ly-6C+ cDCs are precursors of Ly-6C– cDCs. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL25266

24 Samples

Download data: RCC

(Submitter supplied) To identify signature genes associated with nanoparticles carrying IRF5 mRNA treatment on primary macrophages, we analyzed 770 genes in 19 different pathways and processes across 7 different myeloid cell types.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25266

15 Samples

Download data: RCC