Similar studies for GEO DataSets (Select 200066192) - GEO DataSets

(Submitter supplied) The aim of the experiment was to determine the effects of 48 hours of treatment with oxidized low density lipoprotein (oxLDL) on gene expression in primary human monocyte-derived macrophages.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE54666

ID:: 200054666

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001123406.

Differential epigenetic profiling of human aortic endothelial cells (HAEC) in response to shear stress forces

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
32 Samples

Download data: BED

Series

Accession:: GSE112340

ID:: 200112340

PubMed Full text in PMC Similar studies

Select item 2001123367.

Differential epigenetic profiling of human aortic endothelial cells (HAEC) in response to shear stress forces using ChIP-Seq of H3K27ac

(Submitter supplied) Biomechanical cues dynamically control major cellular processes but whether genetic variants actively participate in the mechano-sensing mechanisms remain unexplored. Vascular homeostasis is tightly regulated by hemodynamic forces. Exposure to disturbed blood flow at arterial sites of branching and bifurcation causes constant activation of vascular endothelium contributing to the development of atherosclerosis, the major cause of coronary artery disease (CAD). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
20 Samples

Download data: BED

Series

Accession:: GSE112336

ID:: 200112336

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001123288.

Differential epigenetic profiling of human aortic endothelial cells (HAEC) in response to shear stress forces using ATAC-Seq

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: BED

Series

Accession:: GSE112328

ID:: 200112328

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001573069.

Integrative analysis of liver-specific noncoding regulatory variants associated with the risk of coronary artery disease

(Submitter supplied) We performed promoter Capture Hi-C in HepG2 to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We also performed ChIP-Seq at 2h, 8h and 23h timepoints in HepG2 for Il1B treatment.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL11154
10 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE157306

ID:: 200157306

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Select item 20003016910.

Expression of human aortic endothelial cells treated with or without oxidized phospholipids (II)

(Submitter supplied) Oxidized phospoholipids are a pro-inflammatory component of minimally modified lipoproteins that get trapped in the subendothelial space of atherosclerotic plaques of large arteries. To model the response of endothelial cells in a pro-atherosclerotic enviroment we measured the expression in primary endothelial cells with and without treatment with oxidized phsopolipids from 96 genetically identical donors of anonymous origin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3921
629 Samples

Download data: CDF, CEL

Series

Accession:: GSE30169

ID:: 200030169

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Select item 20002154511.

Biobank of Karolinska Endarterectomy (BiKE)

(Submitter supplied) A biobank collection of carotid plaque samples taken from patients undergoing endarterectomy operations.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
223 Samples

Download data: CEL

Series

Accession:: GSE21545

ID:: 200021545

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Select item 20013751412.

A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer

(Submitter supplied) Interferon beta is a central cytokine in the antiviral response and the immunogenicity of cancer therapies. In monocytes, its expression is modulated by a 60 kb downstream eQTL. We found that this eQTL disrupts binding of the C/EBP-β transcription factor to an enhancer interacting with the IFNB1 promoter. This enhancer, that we have called FIRE for Far IFNB1 Regulatory Enhancer, is conserved in murine myeloid cells, where its looping to Ifnb1 is increased in a genetic model of Ifnb1 deregulation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: BW

Series

Accession:: GSE137514

ID:: 200137514

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Select item 20006136913.

Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci

(Submitter supplied) Recent meta-analyses of genome wide association studies (GWAS) have identified approximately 150 loci that are associated with coronary artery disease (CAD). To link the causal genes in these loci to functional transcriptional networks, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with human coronary artery smooth muscle cells (HCASMC) to investigate the cellular and molecular program downstream of one CAD associated transcription factor, TCF21. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL9115
8 Samples

Download data: BED

Series

Accession:: GSE61369

ID:: 200061369

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Select item 20000713814.

Induction of Dendritic Cell-like Phenotype in Macrophages during Foam Cell Formation

(Submitter supplied) Foam cell formation from monocyte-derived macrophages is a hallmark of atheroscle-rotic lesions. Aspects of this process can be recapitulated in vitro by exposing MCSF-induced or platelet factor4 (CXCL4)-induced macrophages to oxidized (ox) or minimally modified (mm) low density lipoprotein (LDL). We measured gene expression in periph-eral blood mononuclear cells (PBMCs), monocytes and macrophages treated with CXCL1 (GRO-α) or CCL2 (MCP-1) as well as foam cells induced by native LDL, mmLDL or oxLDL using 22 Affymetrix gene chips. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
22 Samples

Download data: CEL

Series

Accession:: GSE7138

ID:: 200007138

Select item 20012275815.

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
12 Samples

Download data: BROADPEAK

Series

Accession:: GSE122758

ID:: 200122758

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Select item 20012275716.

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression [ChIP-Seq]

(Submitter supplied) The majority of genetic variation associated with coronary artery disease (CAD) resides in non- coding regions that are expected to involve transcriptional and epigenetic mechanisms of gene expression. We have identified a transcriptional network downstream of the CAD associated transcription factor (TF) TCF21 and provide evidence for TCF21 colocalization and co- regulation with the activator protein-1 (AP-1) complex in disease loci. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: BED, BROADPEAK

Series

Accession:: GSE122757

ID:: 200122757

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Select item 20012275617.

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression [ATAC-Seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: BED, BROADPEAK

Series

Accession:: GSE122756

ID:: 200122756

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012620018.

Integrative vascular endothelial cell genomics identify AIDA as a coronary artery disease candidate gene

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL20301 GPL16791 GPL24676
40 Samples

Download data: HIC, NARROWPEAK

Series

Accession:: GSE126200

ID:: 200126200

PubMed Full text in PMC Similar studies

Select item 20012619919.

Integrative vascular endothelial cell genomics identify AIDA as a coronary artery disease candidate gene (Hi-C)

(Submitter supplied) Genome-wide association studies (GWAS) have identified 100s of loci associated with coronary artery disease (CAD) and blood pressure (BP)/hypertension. Many of these loci are not associated with traditional risk factors, nor include obvious candidate genes, complicating their functional characterization. We hypothesized that many GWAS loci associated with vascular diseases modulate endothelial functions. more...