Similar studies for GEO DataSets (Select 200102562) - GEO DataSets

Select item 2001025621.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases IV

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
20 Samples

Download data: TXT

Series

Accession:: GSE102562

ID:: 200102562

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Select item 2001025642.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases VI

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
39 Samples

Download data: TXT

Series

Accession:: GSE102564

ID:: 200102564

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Select item 2001025633.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases V

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: TXT

Series

Accession:: GSE102563

ID:: 200102563

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Select item 2001016894.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

4 related Platforms
246 Samples

Download data: RCC

Series

Accession:: GSE101689

ID:: 200101689

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Select item 2001016885.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases III

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23813
50 Samples

Download data: RCC

Series

Accession:: GSE101688

ID:: 200101688

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Select item 2001016876.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases II

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23812
56 Samples

Download data: RCC

Series

Accession:: GSE101687

ID:: 200101687

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Select item 2001016867.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases I

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23811
63 Samples

Download data: RCC

Series

Accession:: GSE101686

ID:: 200101686

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Select item 2001441258.

Lack of TREM2 differentially affects the phenotype and transcriptome of mice expressing human APOE3 and APOE4

(Submitter supplied) We aim to investigate the interaction between two of the major genetic risk factors for AD: inheritance of APOEε4 and deficiency of Triggering Receptor Expressed on Myeloid cells 2 (TREM2). Trem2 deletion worsened memory in AD model mice but not in their WT littermates. Interestingly, the lack Trem2 resulted in a significantly less microglia around amyloid plaques in APP mice expressing both APOE isoforms but had no impact on amyloid load. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
88 Samples

Download data: XLSX

Series

Accession:: GSE144125

ID:: 200144125

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Select item 2001584709.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
46 Samples

Download data: H5, MTX, TSV

Series

Accession:: GSE158470

ID:: 200158470

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Select item 20015846910.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [bulk RNA-seq]

(Submitter supplied) Bulk RNA sequencing data comparing TREM2 WT and KO microglia responses to treatment with dead neurons.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
18 Samples

Download data: H5, TSV

Series

Accession:: GSE158469

ID:: 200158469

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Select item 20015823411.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [scRNA-seq]

(Submitter supplied) scRNA-sequencing of human xenotransplanted microglia isogenic for TREM2 after exposure to amyloid pathology

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE158234

ID:: 200158234

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Select item 20015765212.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer’s pathology in vivo [RNA-seq]

(Submitter supplied) RNA-sequencing of human iPS-microglia isogenic for TREM2 after multiple treatments

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: TXT

Series

Accession:: GSE157652

ID:: 200157652

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Select item 20014074413.

Trem2 effects on brain resident myeloid cells in PS2APP model

(Submitter supplied) Comparing Trem2-KO;PS2APP and Trem2-WT;PS2APP CD11b+ cells reveals the role of Trem2 in microglial gene expression in amyloid-laden brains. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0014430

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
13 Samples

Download data: TSV

Series

Accession:: GSE140744

ID:: 200140744

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Select item 20018562214.

Microglial-expressed Apoe does not modulate plaque pathogenesis

(Submitter supplied) This dataset allows for the exploration of the effect of microglial-expressed Apoe knockout in a 5xFAD Alzheimer's Disease model.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
45 Samples

Download data: XLS

Series

Accession:: GSE185622

ID:: 200185622

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Select item 20013250815.

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

(Submitter supplied) CD33-/- and/or TREM2-/- mice were crossed with the 5xFAD mouse model of Alzheimer’s disease to generate single and double CD33/TREM2 knock-out mice on 5xFAD background. Transcriptome and gene expression analyses were performed to analyze the impact of CD33 and/or TREM2 knock-out on the transcriptome of microglia in the context of amyloid pathology. The results revealed that CD33 and/or TREM2 knock-out reprogrammed microglial gene expression signatures in 5xFAD mice in an age-dependent manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
73 Samples

Download data: XLSX

Series

Accession:: GSE132508

ID:: 200132508

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Select item 20024324316.

Off target expression data from iPSC derived microglia treated with APOE/TREM2 ASOs for 24h/48h. The iPSC cells are from a wild type donor (BIONi10C).

(Submitter supplied) Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, factors for Alzheimer’s disease (AD) highlights the importance of microglial biology in the brain. such as Apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2), as the strongest risk factors for Alzheimer’s disease (AD) highlights the importance of microglial biology in the brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL31262
93 Samples

Download data: CEL

Series

Accession:: GSE243243

ID:: 200243243

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Select item 20021928417.

Alzheimer’s disease neuroinflammatory risk genes can be targeted with RNase-H active antisense oligonucleotides in human microglia

(Submitter supplied) Microglia play important roles in maintaining brain homeostasis. The discovery of genetic variants in the genes encoding Apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2) as the strongest risk factors for Alzheimer’s disease (AD) highlights the importance of microglial biology in the brain. The sequence, structure and function of microglial proteins are poorly conserved across species, and this hampered the development of APOE and TREM2 targeting therapeutic strategies. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL31277
24 Samples

Download data: TXT

Series

Accession:: GSE219284

ID:: 200219284

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Select item 20010990618.

RNAseq of cortex of 6-month old APPPS1 and APPPS1;Apoe-/- mice

(Submitter supplied) One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. ApoE influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in the brain. In addition to influencing Aβ metabolism, increasing evidence suggests that apoE influences microglial function in neurodegenerative diseases. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
13 Samples

Download data: TXT

Series

Accession:: GSE109906

ID:: 200109906

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Select item 20015039419.

A1-Reactive Astrocytes and a loss of TREM2 are associated to an early state of pathology in a mouse model of Cerebral Amyloid Angiopathy

(Submitter supplied) In this study, we dissect in detail the glial and immune responses associated to early stages of CAA. To do so, RNAseq gene expression analysis were performed in a mouse model for Familial Danish Dementia (FDD), a neurodegenerative disease characterized by the accumulation of Danish amyloid (ADan) in the vasculature. Findings observed in this CAA mouse model were complemented with primary culture assays.