Similar studies for GEO DataSets (Select 200130627) - GEO DataSets

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Items: 20

Select item 2001306271.

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103
134 Samples

Download data

Series

Accession:: GSE130627

ID:: 200130627

PubMed Similar studies

Select item 2001340312.

TREM2 regulates microglial lipid metabolism during aging in mice [RNA-Seq]

(Submitter supplied) TREM2 is a microglial-specific gene implicated in late-onset Alzheimer's Disease (AD). Recent studies have identified that Trem2-deficient mice exhibit transcriptional changes in microglial gene expression that minimize the upregulation of lipid metabolism and lysosomal genes in AD disease models. We detect similiarly attenuated expression of lipid metabolism genes in microglia isolated from brains of aged Trem2 knockout mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
56 Samples

Download data: TAB

Series

Accession:: GSE134031

ID:: 200134031

PubMed Similar studies SRA Run Selector

Select item 2001306263.

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [single-cell RNA-Seq]

(Submitter supplied) TREM2 is a microglial-specific gene implicated in late-onset Alzheimer's Disease (AD). Recent studies have identified that Trem2-deficient mice exhibit transcriptional changes in microglial gene expression that minimize the upregulation of lipid metabolism and lysosomal genes in AD disease models. We find that chronic phagocytic challenge from demyelination generates similiarly attenuated expression of lysosomal and lipid metabolism genes in microglia isolated from Trem2 knockout mouse brain.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: CSV, TXT

Series

Accession:: GSE130626

ID:: 200130626

PubMed Similar studies SRA Run Selector

Select item 2001242664.

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]

(Submitter supplied) TREM2 is a microglial-specific gene implicated in late-onset Alzheimer's Disease (AD). Recent studies have identified that Trem2-deficient mice exhibit transcriptional changes in microglial gene expression that minimize the upregulation of lipid metabolism and lysosomal genes in AD disease models. We find that chronic phagocytic challenge from demyelination generates similiarly attenuated expression of lysosomal and lipid metabolism genes in microglia isolated from Trem2 knockout mouse brain.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
74 Samples

Download data: TAB

Series

Accession:: GSE124266

ID:: 200124266

PubMed Similar studies SRA Run Selector

Select item 2000669265.

Expression data from WT and TREM2 deficient microglia in response to cuprizone mediated demyelination

(Submitter supplied) We examined the role of TREM2 on microglia responses to demyelination

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE66926

ID:: 200066926

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001584706.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
46 Samples

Download data: H5, MTX, TSV

Series

Accession:: GSE158470

ID:: 200158470

PubMed Full text in PMC Similar studies

Select item 2001584697.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [bulk RNA-seq]

(Submitter supplied) Bulk RNA sequencing data comparing TREM2 WT and KO microglia responses to treatment with dead neurons.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
18 Samples

Download data: H5, TSV

Series

Accession:: GSE158469

ID:: 200158469

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001582348.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [scRNA-seq]

(Submitter supplied) scRNA-sequencing of human xenotransplanted microglia isogenic for TREM2 after exposure to amyloid pathology

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE158234

ID:: 200158234

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001576529.

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer’s pathology in vivo [RNA-seq]

(Submitter supplied) RNA-sequencing of human iPS-microglia isogenic for TREM2 after multiple treatments

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: TXT

Series

Accession:: GSE157652

ID:: 200157652

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013250810.

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

(Submitter supplied) CD33-/- and/or TREM2-/- mice were crossed with the 5xFAD mouse model of Alzheimer’s disease to generate single and double CD33/TREM2 knock-out mice on 5xFAD background. Transcriptome and gene expression analyses were performed to analyze the impact of CD33 and/or TREM2 knock-out on the transcriptome of microglia in the context of amyloid pathology. The results revealed that CD33 and/or TREM2 knock-out reprogrammed microglial gene expression signatures in 5xFAD mice in an age-dependent manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
73 Samples

Download data: XLSX

Series

Accession:: GSE132508

ID:: 200132508

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015763511.

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

(Submitter supplied) TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. In AD mouse models, knockout (KO) of TREM2 impairs microglial clustering around amyloid, and prevents microglial activation. The R47H mutation is proposed to reduce TREM2 ligand binding. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
9 Samples

Download data: TXT

Series

Accession:: GSE157635

ID:: 200157635

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20020694212.

Trem2 deficiency does not alter virus control but impairs phagocytic activity during neurotropic coronavirus induced demyelination

(Submitter supplied) Triggering receptor expressed on myeloid cells 2 (TREM2) plays a protective role in neurodegenerative diseases, including Alzheimer’s and demyelinating diseases. However, Trem2 functions can exacerbate tissue damage during viral respiratory or liver infections. We therefore investigated the role of TREM2 in a viral encephalomyelitis model associated with prominent Th1 responses and demyelination. To address our hypothesis, Wild type (WT) and Trem2-/- mice were infected with a sublethal glia tropic murine coronavirus (MHV-JHM) was intracranially. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL32396
30 Samples

Download data: RCC

Series

Accession:: GSE206942

ID:: 200206942

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009856313.

TREM2 is a global regulator of microglia energetic and biosynthetic metabolism during steady state and in Alzheimer’s disease

(Submitter supplied) The most common form of senile dementia, Alzheimer’s disease (AD), is characterized by Aβ plaques and neurofibrillary tangles in the CNS. AD genetic studies have identified high-risk hypomorphic variants in TREM2, a myeloid cell surface receptor that enables concerted microglial responses to Aβ plaques and neuronal cell death, including proliferation, survival, clustering and phagocytosis. How TREM2 promotes these responses is not known. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
32 Samples

Download data: TXT

Series

Accession:: GSE98563

ID:: 200098563

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006506714.

Expression data from WT and TREM2 deficient microglia in a mouse model of Alzheimer's disease

(Submitter supplied) We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
20 Samples

Download data: CEL

Series

Accession:: GSE65067

ID:: 200065067

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007047515.

TREM2 regulates microglial cell activation in response to demyelination in vivo

(Submitter supplied) Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in humans cause presenile dementia, while genetic variants are associated with increased risk of neurodegenerative diseases. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10740
18 Samples

Download data: CEL

Series

Accession:: GSE70475

ID:: 200070475

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010256416.

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases VI

(Submitter supplied) Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent molecular signature in microglia isolated from mouse models of amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease (SOD1, EAE and APP-PS1) and in microglia surrounding neuritic A-plaques in human Alzheimer’s disease brain. more...