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Items: 1 to 20 of 164914

1.

Platform-based gene regulation by an endoderm-specific lncRNA via stabilizing nuclear speckles

(Submitter supplied) Nuclear speckles (NSs), one of the key non-membrane nuclear bodies, participate in transcription, RNA processing, and chromatin organization, yet their precise functions and mechanisms in vivo remain elusive. Here we show that Falcor, an endoderm-specific long non-coding RNA (lncRNA), is necessary and sufficient for maintaining structural integrity of NSs in mouse liver cells. Disruption and reinstatement of NSs by Falcor coordinately regulate more than one thousand genes, including those related to metabolic processes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
46 Samples
Download data: TXT
Series
Accession:
GSE267072
ID:
200267072

2.

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver]

(Submitter supplied) RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
61 Samples
Download data: CSV
Series
Accession:
GSE266923
ID:
200266923

3.

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [skeletal muscle]

(Submitter supplied) RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
61 Samples
Download data: CSV
Series
Accession:
GSE266922
ID:
200266922

4.

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [Islet]

(Submitter supplied) RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
95 Samples
Download data: CSV
Series
Accession:
GSE266921
ID:
200266921

5.

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [Adipose]

(Submitter supplied) RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
61 Samples
Download data: CSV
Series
Accession:
GSE266920
ID:
200266920

6.

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart]

(Submitter supplied) RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
63 Samples
Download data: CSV
Series
Accession:
GSE266918
ID:
200266918

7.

Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice

(Submitter supplied) In the present study, we explored whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic disorders using skeletal muscle Cth knockout (CthΔskm) mice. Metabolomics coupled with transcriptome showed that CthΔskm mice displayed impaired energy metabolism and some signaling pathways linked to insulin resistance (IR) in skeletal muscle although the mice had normal insulin sensitivity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
32 Samples
Download data: TXT
Series
Accession:
GSE254704
ID:
200254704

8.

Cyclo His-Pro halts skeletal muscle degeneration and cardiomyopathy in murine myopathy models

(Submitter supplied) Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. Caused by the absence of functional dystrophin, DMD pathogenesis is driven by the progressive degeneration of muscle fibers, resulting in the development of inflammation and fibrosis that ultimately affect the overall muscle biomechanics. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23479 GPL24247
38 Samples
Download data: CSV
Series
Accession:
GSE241771
ID:
200241771

9.

Single nucleus RNA sequencing analysis of vagal sensory neurons

(Submitter supplied) We report that molecularly distinct populations of vagal sensory neurons would play a role in causing differences in metabolic homeostasis between the sexes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE267231
ID:
200267231

10.

Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [Liver]

(Submitter supplied) Perform RNAseq with existing frozen mouse DO tissues from ~500 DO mice were sensitized on a HFHS diet (Keller, Gatti et al. 2018). The same mice have been extensively characterized for T2D-relevant clinical phenotypes, ex-vivo islet function, and other features including microbiome profiling. Gene expression and proteomic profiling has already been completed in islets. We will collect and analyze the genetic architecture of gene expression in liver, adipose, skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
481 Samples
Download data: CSV
Series
Accession:
GSE266569
ID:
200266569

11.

Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [skeletal muscle]

(Submitter supplied) Perform RNAseq with existing frozen mouse DO tissues from ~500 DO mice were sensitized on a HFHS diet (Keller, Gatti et al. 2018). The same mice have been extensively characterized for T2D-relevant clinical phenotypes, ex-vivo islet function, and other features including microbiome profiling. Gene expression and proteomic profiling has already been completed in islets. We will collect and analyze the genetic architecture of gene expression in liver, adipose, skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
474 Samples
Download data: CSV
Series
Accession:
GSE266567
ID:
200266567

12.

Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [Adipose]

(Submitter supplied) Perform RNAseq with existing frozen mouse DO tissues from ~500 DO mice were sensitized on a HFHS diet (Keller, Gatti et al. 2018). The same mice have been extensively characterized for T2D-relevant clinical phenotypes, ex-vivo islet function, and other features including microbiome profiling. Gene expression and proteomic profiling has already been completed in islets. We will collect and analyze the genetic architecture of gene expression in liver, adipose, skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
468 Samples
Download data: CSV
Series
Accession:
GSE266549
ID:
200266549

13.

Fasting prior to cisplatin treatment alleviates nephrotoxicity, enhances survival and potentiates senescence-related pathways in mice

(Submitter supplied) To investigate the protective effects of pre-therapy fasting on cisplatin-induced nephrotoxicity.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: TXT
Series
Accession:
GSE214999
ID:
200214999

14.

A systems-level analysis of bile acids effects on rat colon epithelial cells

(Submitter supplied) Bile acid diarrhoea is a chronic condition caused by increased delivery of bile acids to the colon. The underlying mechanisms remain to be elucidated. To investigate genes involved in bile acid diarrhoea, systems-level analyses were employed on a rat bile acid diarrhoea model. Twelve male Wistar Munich rats, housed in metabolic cages, were fed either control or bile acid-mixed (1% w/w) diets for ten days. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
10 Samples
Download data: GFF, TXT
Series
Accession:
GSE174249
ID:
200174249

SRA Run Selector

15.

The Histone Methyltransferase SUV420H2 Regulates Brown and Beige Adipocyte Thermogenesis (ATAC-Seq)

(Submitter supplied) Activation of brown adipose tissue (BAT) thermogenesis increases energy expenditure and alleviates obesity. Epigenetic regulation has emerged as a key mechanism underlying BAT development and function. To study the epigenetic regulation of BAT thermogenesis, we surveyed the expression of epigenetic enzymes that catalyze histone modifications in developmental beige adipocytes and found a unique expression pattern of suppressor of variegation 4-20 homolog 2 (Drosophila) (Suv420h2), a histone methyltransferase that preferentially catalyzes the tri-methylation at histone H4 lysine 20 (H4K20me3), a hallmark of gene silencing. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: BIGWIG
Series
Accession:
GSE245509
ID:
200245509

16.

The Histone Methyltransferase SUV420H2 Regulates Brown and Beige Adipocyte Thermogenesis

(Submitter supplied) Activation of brown adipose tissue (BAT) thermogenesis increases energy expenditure and alleviates obesity. Epigenetic regulation has emerged as a key mechanism underlying BAT development and function. To study the epigenetic regulation of BAT thermogenesis, we surveyed the expression of epigenetic enzymes that catalyze histone modifications in developmental beige adipocytes and found a unique expression pattern of suppressor of variegation 4-20 homolog 2 (Drosophila) (Suv420h2), a histone methyltransferase that preferentially catalyzes the tri-methylation at histone H4 lysine 20 (H4K20me3), a hallmark of gene silencing. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE244457
ID:
200244457

17.

Elucidating the Onset of Cross-protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2

(Submitter supplied) African swine fever (ASF) is a deadly disease of swine currently causing a worldwide pandemic leading to severe economic consequences for the porcine industry. The control of disease spread is hampered by the limitation of available effective vaccines. Live attenuated vaccines (LAVs) are currently the most advanced vaccine prototypes, providing strong protection against ASF. However, the significant advances achieved using LAVs must be complemented with further studies to analyse vaccine-induced immunity. more...
Organism:
Sus scrofa domesticus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29562
60 Samples
Download data: TXT
Series
Accession:
GSE266565
ID:
200266565

18.

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

(Submitter supplied) Pregannt Cyp19-EGFP mice (maintained on a soybean free mouse chow diet) were treated with either 50μg/kg/day Bsiphenol A or vehicle (ethinol in peanut oil) between gestational days (GD) 10.5-14.5. On GD15.5, fetuses were dissected and sex determined by SRY genotyping. Fetuses were obtained from different dams.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16417
6 Samples
Download data: CSV
Series
Accession:
GSE266401
ID:
200266401

19.

Therapeutic targeting of PKM2 ameliorates NASH fibrosis progression in a macrophage-specific and liver-specific manner

(Submitter supplied) Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage liver disease worldwide with limited treatment options. Liver fibrosis, driven by chronic inflammation and hepatic stellate cells (HSCs) activation, critically determines morbidity and mortality in patients with NASH. Pyruvate kinase M2 (PKM2) is involved in immune activation and inflammatory liver diseases; however, its role and therapeutic potential in NASH fibrosis remain largely unexplored. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE266040
ID:
200266040

20.

Semaglutide interferes with postnatal growth in a diet-dependent manner

(Submitter supplied) Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to impact glucose homeostasis and, more recently, the somatotropic axis. While the effects of GLP-1RAs have been extensively studied in the context of diet-induced obesity, their impact on physiology in other nutritional contexts have been less explored. We investigated the potential beneficial effects of the GLP-1RA semaglutide during juvenile protein malnutrition, a dietary challenge known to cause stunted growth and to disrupt metabolic homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
10 Samples
Download data: TSV
Series
Accession:
GSE266477
ID:
200266477

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