|
| Status |
Public on Sep 26, 2017 |
| Title |
Global modulation of signaling pathways by SARM RAD140 in AR/ER+ breast cancer xenografts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
These data demonstrates the regulation of AR and ER pathways by the SARM RAD140 and suggested a unique mechanism of action of RAD140 via the AR-mediated transcription repression.
|
| |
|
| Overall design |
HBCx-22 PDX were treated with RAD140 or vehicle and snap frozen tumor samples were subjected to RNA-seq analysis at the end of the study
|
| |
|
| Contributor(s) |
Wang D, He S, Yu Z |
| Citation(s) |
28974548 |
| Submission date |
Sep 25, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
ZiYang Yu |
| E-mail(s) |
zyu@radiuspharm.com
|
| Phone |
617-551-4065
|
| Organization name |
Radius Health
|
| Street address |
950 Winter Street
|
| City |
Waltham |
| State/province |
MA |
| ZIP/Postal code |
02451 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA411985 |
| SRA |
SRP118776 |
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