|
Status |
Public on Sep 26, 2017 |
Title |
Global modulation of signaling pathways by SARM RAD140 in AR/ER+ breast cancer xenografts |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
These data demonstrates the regulation of AR and ER pathways by the SARM RAD140 and suggested a unique mechanism of action of RAD140 via the AR-mediated transcription repression.
|
|
|
Overall design |
HBCx-22 PDX were treated with RAD140 or vehicle and snap frozen tumor samples were subjected to RNA-seq analysis at the end of the study
|
|
|
Contributor(s) |
Wang D, He S, Yu Z |
Citation(s) |
28974548 |
|
Submission date |
Sep 25, 2017 |
Last update date |
May 15, 2019 |
Contact name |
ZiYang Yu |
E-mail(s) |
zyu@radiuspharm.com
|
Phone |
617-551-4065
|
Organization name |
Radius Health
|
Street address |
950 Winter Street
|
City |
Waltham |
State/province |
MA |
ZIP/Postal code |
02451 |
Country |
USA |
|
|
Platforms (1) |
GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
Samples (6)
|
|
Relations |
BioProject |
PRJNA411985 |
SRA |
SRP118776 |