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| Status |
Public on Oct 17, 2019 |
| Title |
SMAD1/5 binding pattern in human pulmonary arterial endothelial cells [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We showed that the BMPRII/ALK-1/SMAD/ATOH8 axis protects against the development of pulmonary arterial hypertension (PAH). We have performed ChIP-seq analyses to reveal the function of both SMAD and ATOH8.
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| Overall design |
SMAD1/5 ChIP-seq analyses were performed in human pulmonary arterial endothelial cells (HPAECs) treated with 1 ng/ml BMP-9 for 1.5 h (biological duplicate). FLAG ChIP-seq alalysis was performed in HPAEC stably expressing FLAG-ATOH8.
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| |
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| Contributor(s) |
Morikawa M, Koinuma D, Heldin C, Miyazono K |
| Citation(s) |
31719172 |
| Submission date |
Oct 06, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Masato Morikawa |
| E-mail(s) |
morikawa-tky@umin.ac.jp
|
| Phone |
+81-3-3964-1211
|
| Organization name |
Teikyo University
|
| Department |
Advanced Comprehensive Research Organization
|
| Street address |
2-21-1 Kaga, Itabashi-ku
|
| City |
Tokyo |
| ZIP/Postal code |
173-0003 |
| Country |
Japan |
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| Platforms (1) |
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| Samples (5)
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| GSM2805410 |
SMAD1/5 ChIP-seq, HPAEC BMP-9 1.5h, rep1 |
| GSM2805411 |
SMAD1/5 ChIP-seq, HPAEC BMP-9 1.5h, rep2 |
| GSM2805412 |
FLAG-ATOH8 ChIP-seq, HPAEC-FA8, rep1 |
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| This SubSeries is part of SuperSeries: |
| GSE104685 |
The analysis of the role of ALK-1/SMAD/ATOH8 axis in endothelial cells |
|
| Relations |
| BioProject |
PRJNA413500 |
| SRA |
SRP119512 |
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