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| Status |
Public on Jul 01, 2019 |
| Title |
The olfactory molecular snapshot of Tg2576 mice at early stages of amyloid pathology |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Olfaction is often deregulated in Alzheimer's disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in Tg2576 mice. For that, we have applied proteome- and transcriptome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from Tg2576 mice (2, and 6 months of age) respect to age-matched wild-type (WT) littermates.
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| Overall design |
Olfactory bulbs from 3 WT mice vs. olfactory bulbs from 3 Tg2576 transgenic mice in each time point.
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| Contributor(s) |
Santamaría E |
| Citation(s) |
31244650 |
| Submission date |
Nov 07, 2017 |
| Last update date |
Jul 01, 2019 |
| Contact name |
Victor Segura |
| E-mail(s) |
vsegura@unav.es
|
| Organization name |
FIMA
|
| Department |
Unit of Proteomics, Genomics and Bioinformatics
|
| Street address |
Avda. Pío XII, 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA417496 |
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