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| Status |
Public on Dec 04, 2018 |
| Title |
Gene expression profiling of PBMCs in dairy cows pre- and post-partum |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The transition to lactation challenges dairy cows metabolically. Immune dysfunction and infectious disease risk is the hallmark of this transition period. Transcriptome data of PBMC shows differentially expressed pathways postpartum. Metabolically stressed cows show upregulation of innate immune pathways and inflammation.
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| Overall design |
Gene expression profiling of PMBCs from 6 dairy cows, each sampled 21 days prepartum and 7 days postpartum. Three cows (H1-3) showed signs of increased metabolic stress (by other assays) relative to the other three cows (L1-3).
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| Contributor(s) |
Mann S, Sipka A, Grenier JK |
| Citation(s) |
30500340 |
| Submission date |
Aug 03, 2018 |
| Last update date |
Dec 04, 2018 |
| Contact name |
Jennifer K Grenier |
| Organization name |
Cornell University
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| Department |
Biomedical Sciences
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| Lab |
Biotechnology Building rm 333
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| Street address |
526 Campus Rd
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| City |
Ithaca |
| State/province |
NY |
| ZIP/Postal code |
14853 |
| Country |
USA |
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| Platforms (1) |
| GPL23055 |
Illumina NextSeq 500 (Bos taurus) |
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| Samples (12)
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| GSM3318675 |
Group H, Cow 4, pre |
| GSM3318676 |
Group H, Cow 5, pre |
| GSM3318677 |
Group H, Cow 6, pre |
| GSM3318678 |
Group L, Cow 1, post |
| GSM3318679 |
Group L, Cow 2, post |
| GSM3318680 |
Group L, Cow 3, post |
| GSM3318681 |
Group H, Cow 4, post |
| GSM3318682 |
Group H, Cow 5, post |
| GSM3318683 |
Group H, Cow 6, post |
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| Relations |
| BioProject |
PRJNA484415 |
| SRA |
SRP156321 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE118108_4groups_gene_exp.diff.gz |
3.4 Mb |
(ftp)(http) |
DIFF |
| GSE118108_PreVPost_gene_exp.diff.gz |
885.1 Kb |
(ftp)(http) |
DIFF |
| GSE118108_genes.read_group_tracking.txt.gz |
2.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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