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| Status |
Public on Feb 16, 2021 |
| Title |
lncRNA sequencing of human ovarian cancer cell SKOV3 after exposure to ginsenoside 20(S)-Rg3 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Ginsenoside 20(S)-Rg3, an active saponin monomer extracted from red ginseng, inhibits the malignancy of ovarian cancer cells. RNA-Seq analysis was used for deep sequencing of lncRNA to detected molecular mechanisms of 20(S)-Rg3.We identified 85 differentially expressed lncRNA influenced by 20(S)-Rg3, among which 67 lncRNAs were significantly decreased (fold change<0.5, p<0.05) including 12 ncRNAs and 55 pseudo genes, and 18 lncRNAs were significantly increased (fold change>1.5, p<0.05) including 3 ncRNAs, 14 pseudo genes and 1 unknown gene. This study provide a valuable resource for the discovery of lncRNAs related to anti-tumor mechanism of 20(S)-Rg3.
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| Overall design |
lncRNA of SKOV3 ovarian cancer cells treated with 80 μg/mL 20(S)-Rg3 for 24 h and negative control cells were generated by deep sequencing using the Ion Torrent Proton platform.
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| Contributor(s) |
Li X, Zhao L |
| Citation(s) |
30481782 |
| Submission date |
Aug 07, 2018 |
| Last update date |
Feb 16, 2021 |
| Contact name |
zhao le |
| E-mail(s) |
zhaole2@mail.xjtu.edu.cn
|
| Organization name |
The First Affiliated Hospital of Xi'an Jiao Tong University
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| Street address |
Yanta Western Road NO.227
|
| City |
xian |
| ZIP/Postal code |
710061 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA484884 |
| SRA |
SRP156534 |
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