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| Status |
Public on May 20, 2023 |
| Title |
An ethanol extract of Coptidis rhizoma induces apoptotic cell death in induced pluripotent stem cells and suppress teratoma formation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We explored whether an ethanol extract of coptidis rhizoma (ECR) exhibited anti-teratoma activity and identified the main active components involved in the selective elimination of undifferentiated iPSCs.
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| Overall design |
We profiled gene expresion in vehicle-treated iPSCs (control) and iPSCs treated with 5 μg/mL of an ECR (ECR-Low) or 10 μg/mL of an ECR (ECR_High).
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| |
|
| Contributor(s) |
Kim A, Chung S, Baek S |
| Citation(s) |
37242247 |
| Submission date |
Feb 21, 2023 |
| Last update date |
Aug 25, 2023 |
| Contact name |
Su-Jin Baek |
| Organization name |
KOREA INSTITUTE of ORIENTAL MEDICINE
|
| Street address |
1672, Yuseong-daero
|
| City |
Daejeon |
| ZIP/Postal code |
34054 |
| Country |
South Korea |
| |
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| Platforms (1) |
|
| Samples (9)
|
| GSM7054531 |
iPSCs treated with vehicle (replicate 1) |
| GSM7054532 |
iPSCs treated with vehicle (replicate 2) |
| GSM7054533 |
iPSCs treated with vehicle (replicate 3) |
| GSM7054534 |
iPSCs treated with 5 μg/mL ECR (replicate 1) |
| GSM7054535 |
iPSCs treated with 5 μg/mL ECR (replicate 2) |
| GSM7054536 |
iPSCs treated with 5 μg/mL ECR (replicate 3) |
| GSM7054537 |
iPSCs treated with 10 μg/mL ECR (replicate 1) |
| GSM7054538 |
iPSCs treated with 10 μg/mL ECR (replicate 2) |
| GSM7054539 |
iPSCs treated with 10 μg/mL ECR (replicate 3) |
|
| Relations |
| BioProject |
PRJNA937203 |
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