|
| Status |
Public on May 14, 2024 |
| Title |
Small molecule TERT activator prevents aging and cognitive decline [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We discovered a novel small-molecule TERT activating compound (TAC) that selectively enhances TERT transcription in human and mouse adult somatic cells. Our findings also provide the novel mechanism of TAC-mediated TERT up-regulation and elucidate the impact of TERT induction on regulatory factors governing aging.
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| |
|
| Overall design |
Profiling of histone modifcation and TF binding in human somatic cells.
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| |
|
| Contributor(s) |
Shim HS |
| Citation missing |
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| Submission date |
May 02, 2023 |
| Last update date |
May 15, 2024 |
| Contact name |
Hong Seok Shim |
| E-mail(s) |
hshim@mdanderson.org
|
| Organization name |
MD Anderson Cancer Center
|
| Street address |
1881 East Rd, 3SCR5.4420
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA966085 |
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