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| Status |
Public on Jan 24, 2024 |
| Title |
Deep phenotyping of Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [Protein plasma] |
| Organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
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| Summary |
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disorder that may occur following an infection, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit a cohort of post-infectious ME/CFS (PI-ME/CFS) volunteers (n=17) with matched healthy controls (n=21) to conduct deep clinical and biological phenotyping using an extensive battery of tests. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical deconditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
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| Overall design |
The proteome for 42 separate Plasma samples were profiled using the SOMAscan human proteomic assay. Samples included 21 individuals diagnosed with Chronic Fatigue Syndrome (9 Male, 12 Female) and 21 Controls (10 Male, 11 Female).
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| Contributor(s) |
Walitt B, Singh K, Hallett M, Jacobson S, Chen K, Akahata YE, Apps R, Barb JJ, Bedard P, Brychta RJ, Buckley AW, Burbelo PD, Calco B, Cathay B, Chen L, Chen J, Cheung F, Chigurupati S, Chin LM, Coleman BW, Courville AB, Deming MS, Drinkard B, Feng LR, Ferrucci L, Gabel SA, Gavin A, Goldstein DS, Hassanzadeh S, Horan SC, Horovitz SG, Johnson KR, Govan AJ, Knutson KM, Kreskow JD, LaMunion SR, Levin M, Lyons JJ, Madian N, Malik N, Mammen AL, McCulloch JA, McGurrin PM, Milner JD, Moaddel R, Mueller GA, Mukherjee A, Braceras SM, Norato G, Pak K, Pinal-Fernandez I, Popa T, Reoma LB, Sack MN, Saligan LN, Sellers BA, Sinclair S, Smith B, Snow J, Solin S, Stussman BJ, Trinchieri G, Turner SA, Vetter CS, Vial F, Vizioli C, Williams A, Yang SB, Nath A |
| Citation(s) |
38383456 |
| BioProject |
PRJNA1055468 |
| Submission date |
Jan 23, 2024 |
| Last update date |
Mar 06, 2024 |
| Contact name |
Avindra Nath |
| E-mail(s) |
avindra.nath@nih.gov
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| Phone |
3014961561
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| Organization name |
NIH/NINDS
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| Street address |
10 Center Drive
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| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20814 |
| Country |
USA |
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| Platforms (1) |
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| Samples (42)
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| This SubSeries is part of SuperSeries: |
| GSE251792 |
Deep phenotyping of Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
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| Supplementary file |
Size |
Download |
File type/resource |
| GSE254030_CHI-19-021.Plasma_for_CFS.adat.txt.gz |
245.1 Kb |
(ftp)(http) |
TXT |
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