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| Status |
Public on Apr 27, 2024 |
| Title |
Expression data from neural stem cells of adult mice brains in TCQA- and TFQA- treatments |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TCQA- and TFQA- treatments in NSCs showed the significant performance on improving neurogenesis compared with no- treatment NSCs. TCQA and TFQA‐ treatments in NSCs also had significant activation of ErbB signaling pathway, AKT and MAPK kinases. Among them, TCQA- treatment upregulated Myc gene when Jun was mediated in TFQA- treatment, which stimulated the functions of enhancing synaptic growth and neuron differentiation.
We used microarrays to detail the global programme of gene expression underlying treatment and identified distinct classes of regulated genes during this process.
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| Overall design |
Neural stem cells of adult mice brains were selected for RNA extraction on Affymetrix microarrays. We selected 6-8 weeks old adult male ICR mice for neural stem cell extraction. After two weeks of incubation, TCQA- and TFQA- treatments for 72 h were performed.
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| Contributor(s) |
Lin H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 22, 2024 |
| Last update date |
Apr 27, 2024 |
| Contact name |
Hongyu Lin |
| E-mail(s) |
linhongyu1hk@gmail.com
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| Phone |
+8615521299752
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| Organization name |
University of Tsukuba
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| Department |
Life and Earth Sciences
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| Lab |
ISODA Lab.
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| Street address |
Tennodai 1-1-1
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| City |
Tsukuba City |
| State/province |
Ibaraki |
| ZIP/Postal code |
305-8577 |
| Country |
Japan |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA1103112 |
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