|
| Status |
Public on Nov 26, 2011 |
| Title |
Genomic characterization of the MPNST |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by array
|
| Summary |
Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. By characterizing recurrent gene copy number aberrations, we gain insight into the most altered pathways with the purpose of scanning possible therapeutic targets.
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| Overall design |
We conducted a microarray-based comparative genomic hybridization profiling of two cohorts of primary MPNST tissue samples including 25 patients treated at The University of Texas MD Anderson Cancer Center and 26 patients from Tianjin Cancer Hospital. All samples had at least 90% tumor content. Commercially available normal genomic DNAs were used as control.
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| |
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| Contributor(s) |
Yang J, Ylipää A, Sun Y, Zheng H, Chen K, Nykter M, Trent J, Ratner N, Lev DC, Zhang W |
| Citation(s) |
22042973 |
| Submission date |
Nov 22, 2011 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Antti Ylipää |
| E-mail(s) |
antti.ylipaa@tut.fi
|
| Organization name |
Tampere University of Technology
|
| Street address |
Korkeakoulunkatu 1
|
| City |
Tampere |
| ZIP/Postal code |
33101 |
| Country |
Finland |
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| Platforms (1) |
| GPL5477 |
Agilent-014950 Human Genome CGH Microarray 4x44K (Feature Number version) |
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| Samples (51)
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| Relations |
| BioProject |
PRJNA148353 |
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