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Series GSE40465 Query DataSets for GSE40465
Status Public on Oct 15, 2014
Title Large-Scale Identification of Coregulated Enhancer Networks in the Adult Human Brain
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The complexity of the brain and the links entailed to its functional diversity remain a major challenge of biology to understand. Distinct anatomical areas regulate a vast array of processes including organismal homeostasis, cognitive functions and susceptibility to neurological pathologies, many of which define our species. Distal enhancers have emerged as key regulatory elements that acquire epigenetic modifications in a cell-type specific manner, thus enforcing cell- and species-specific gene expression programs. Here, we survey the epigenetic landscape of promoters and cis-regulatory elements in 87 anatomically distinct regions of the human brain, spanning over a hundred different anatomical structures.
 
Overall design ChIP-Seq of various regions of the human brain. Also includes mouse and rat samples.

Contributor: The Netherlands Brain Bank
 
Contributor(s) Vermunt MW, Reinink P, Korving J, de Bruijn E, Creygthon PM, Basak O, Geeven G, Toonen PW, Lansu N, Meunier C, van Heesch S, Clevers H, de Laat W, Cuppen E, Creyghton MP
Citation(s) 25373911
Submission date Aug 29, 2012
Last update date May 15, 2019
Contact name Menno P Creyghton
E-mail(s) m.creyghton@hubrecht.eu
Organization name Hubrecht Institute
Lab Creyghton
Street address Uppsalalaan 8
City Utrecht
ZIP/Postal code 3584 CT
Country Netherlands
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL16288 AB 5500xl Genetic Analyzer (Homo sapiens)
Samples (151)
GSM1119116 Region_1 - Posterior Precentral Gyrus, Brain1, H3K27ac ChIP
GSM1119117 Region_2 - Locus Coeruleus, Brain1, H3K27ac ChIP
GSM1119118 Region_3 - Occipital Pole, Brain1, H3K27ac ChIP
Relations
BioProject PRJNA174097
SRA SRP015316

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40465_RAW.tar 52.5 Gb (http)(custom) TAR (of BED, BEDGRAPH, BW, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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