|
| Status |
Public on Sep 09, 2014 |
| Title |
Genome-wide analysis of the Integrator complex (HTS) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
We investigated the genomic occupancy of INTS11, in normal condition and after stimulation of EGF. Total RNAPII was profiled in the presence or absence of INTS11, along with the Super Elongation Complex proteins AFF4 and ELL2. Additionally, we extensively examined the transcriptional response to EGF, before and after depletion of INTS11, using RNA-seq on ribosome-depleted total RNA and Global Run-on sequencing (GRO-seq).
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| |
|
| Overall design |
Comparison of the genome-wide profiles of INTS11 and RNAPII in HeLa cells.
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| |
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| Contributor(s) |
Gardini A, Baillat D, Cesaroni M, Hu D, Shiekhattar R |
| Citation(s) |
25201415, 36920904 |
| Submission date |
Sep 05, 2012 |
| Last update date |
Sep 11, 2023 |
| Contact name |
Alessandro Gardini |
| E-mail(s) |
agardini@wistar.org
|
| Phone |
305-243-7394
|
| Organization name |
University of Miami
|
| Department |
Sylvester Comprehensive Cancer Center
|
| Lab |
Ramin Shiekhattar
|
| Street address |
1501 NW 10 Avenue
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (46)
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| This SubSeries is part of SuperSeries: |
| GSE58255 |
Genome-wide analysis of the Integrator complex |
|
| Relations |
| BioProject |
PRJNA174441 |
| SRA |
SRP015419 |
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