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Series GSE43027 Query DataSets for GSE43027
Status Public on Dec 20, 2012
Title An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in Uterine Leiomyomas
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Copy number alterations data and transcriptional profiling of uterine leiomyomas tumor samples for integrative analysis. Goal was to determine identify genomic gains and/or losses associated with up and/or down expressed genes, respectively. After, it was applied GSEA and CONEXIC algorithm to integrate the data. Protein-Protein interactions also was building and the data were validated using qRT-PCR and IHC techniques.
 
Overall design Experiment condition, 51 uterine leiomyoma DNA samples obtained from patients at secretory and proliferative menstrual cycle phases were labeled with Cy5 or Cy3 and commercial reference samples (Promega) were labled with Cy5 or Cy3. Samples Cy3 and Cy5 were mixed and hybridized at slide glasses Agilent 4x44 platform. See GSE43027 for the gene expression component.
 
Contributor(s) Cirilo PD, Marchi FA
Citation(s) 23483937
Submission date Dec 19, 2012
Last update date Mar 17, 2013
Contact name Priscila Daniele Ramos Cirilo
Organization name Instituto de Biociências de Botucatu
Department Genética
Lab NeoGene
Street address Distrito de Rubião Junior S/N
City Botucatu
State/province SP
ZIP/Postal code 18618-970
Country Brazil
 
Platforms (1)
GPL5477 Agilent-014950 Human Genome CGH Microarray 4x44K (Feature Number version)
Samples (51)
GSM1055219 Uterine leiomyoma tumor 614 Proliferative
GSM1055220 Uterine leiomyoma tumor 615 Proliferative
GSM1055221 Uterine leiomyoma tumor 625 Secretory
Relations
BioProject PRJNA184073

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43027_RAW.tar 234.9 Mb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file
Processed data included within Sample table
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