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Series GSE53728 Query DataSets for GSE53728
Status Public on Dec 31, 2013
Title Geriatric muscle stem cells switch reversible quiescence into senescence
Organism Mus musculus
Experiment type Expression profiling by array
Summary Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging and in progeric conditions. Here we show that geriatric satellite cells, compared to old cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
 
Overall design Refer to individual Series
 
Contributor(s) Perdiguero E, Munoz-Canoves P
Citation(s) 24522534
Submission date Dec 30, 2013
Last update date Jul 19, 2017
Contact name Eusebio Perdiguero
E-mail(s) perdiguero@gmail.com
Organization name UPF
Department Department of Medicine and Life Sciences
Lab Cell Biology
Street address Dr. Aiguader 88
City Barcelona
ZIP/Postal code 08003
Country Spain
 
Platforms (1)
GPL13912 Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)
Samples (36)
GSM1299431 Satellite_cells_Young_mice_biological_replicate_1 [Set 1]
GSM1299432 Satellite_cells_Young_mice_biological_replicate_2 [Set 1]
GSM1299433 Satellite_cells_Young_mice_biological_replicate_3 [Set 1]
This SuperSeries is composed of the following SubSeries:
GSE53724 Geriatric muscle stem cells switch reversible quiescence into senescence (Set 1; Geriatric vs. Young)
GSE53725 Geriatric muscle stem cells switch reversible quiescence into senescence (Set 2; Old/Geriatric vs. Young and SAMR1 vs. SAMP8)
GSE53726 Geriatric muscle stem cells switch reversible quiescence into senescence (Set 3; Adult vs. Young)
Relations
BioProject PRJNA232724

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53728_RAW.tar 431.9 Mb (http)(custom) TAR (of TXT)

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