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| Status |
Public on May 30, 2016 |
| Title |
Impaired DNA damage metabolism promotes autoimmunity in TREX1 deficiency |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Constitutive low level DNA damage is linked to innate immune activation. Hierarchical clustering of over 9000 transcripts revealed remarkably similar profiles in a patient with lupus erythematosus and a patient with AGS with up-regulation of genes involved in DNA damage signaling, p53-inducible genes, senescence-associated genes as well as up-regulation of interferon-stimulated genes. Transcriptional profiling of fibroblasts exposed to oxidative stress showed a marked up-regulation of genes involved in DNA replication/repair and replication licensing in TREX1-deficient cells compared to wild type cells suggesting massive replication stress.
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| |
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| Overall design |
Comparison of transcriptional profiles of unstressed patient fibroblasts with wild type cells as well as fibroblasts exposed to oxidative stress
|
| |
|
| Contributor(s) |
Wolf C, Berndt N, Rapp A, Dobrick-Mattheuer M, Kretschmer S, Krug C, Kurth T, Wieczorek D, Alexopoulou D, Dahl A, Cardoso MC, Günther C, Lee-Kirsch MA |
| Citation(s) |
27230542 |
| Submission date |
Jul 09, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Min Ae Lee-Kirsch |
| E-mail(s) |
MinAe.Lee-Kirsch@uniklinikum-dresden.de
|
| Organization name |
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
|
| Department |
Klinik für Kinder- und Jugendmedizin
|
| Lab |
Molekulare Pädiatrie
|
| Street address |
Fetscherstr. 74
|
| City |
Dresden |
| ZIP/Postal code |
01307 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA254790 |
| SRA |
SRP044181 |
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