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Series GSE67287 Query DataSets for GSE67287
Status Public on Nov 01, 2015
Title The effect of age on alternative splicing in different tissues of wild-type mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Exon level expression analysis for the physiological aging study data set to analyze the effect of age on alternative splicing in different tissues and age groups of wild-type mice
Analysis of the effect of age on alternative splicing (AS) using exon microarrays to interrogate the differential exon usage of the entire genome of aging wild-type male C57BL/6J mice (4- and 18-month-old) in five tissues (skin, skeletal muscle, bone, thymus, and white adipose tissue) and in an additional 28-month-old age group, which allowed for age-related AS analysis of the skin, skeletal muscle and bone tissues. We found AS genes with age in all tissue, we show that the number of AS genes increased with age and that AS genes across all tissues are involved in RNA processing. Note: This dataset is one of the 2 datasets in the overall study. An additional data set series is available with exon expression analysis of HGPS mice to analyze the effect of progerin expression on alternative splicing. The two datasets are linked together in the SuperSeries GSE67289. A link to the SuperSeries is available at the bottom of this page.
 
Overall design 65 tissue samples from wild-type male C57BL/6J mice; from 5 different tissues (ventral skin, skeletal muscle, bone, muscle, and white adipose tissue) and from 3 different age groups: 4, 18 and 28 months (for skin skeletal muscle and bone ) and from 2 different age groups: 4 and 18 months (for ventral skin, skeletal muscle, bone, thymus and white adipose tissue)
 
Contributor(s) Rodriguez SA, Brodin D, Eriksson M
Citation(s) 26685868
Submission date Mar 25, 2015
Last update date Mar 03, 2017
Contact name Maria Eriksson
E-mail(s) maria.eriksson.2@ki.se
Organization name Karolinska Institutet
Department Biosciences and Nutrition
Lab Maria Eriksson
Street address Hälsovägen 7
City Huddinge
ZIP/Postal code 14183
Country Sweden
 
Platforms (1)
GPL6193 [MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version]
Samples (65)
GSM1643819 A16_bone_4months, biological rep1
GSM1643820 A17_bone_4months, biological rep2
GSM1643821 A18_bone_4months, biological rep3
This SubSeries is part of SuperSeries:
GSE67289 The effect of age and progerin expression on alternative splicing in selected tissues in mice
Relations
BioProject PRJNA279416

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE67287_RAW.tar 1.4 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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