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| Status |
Public on Nov 01, 2015 |
| Title |
The effect of progerin expression on alternative splicing in keratinocytes of HGPS mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Exon level expression analysis for the HGPS pathological aging study data set to analyze the effect of progerin expression on alternative splicing in keratinocytes of HGPS mice.
Analysis of the effect of pathological aging (transgenic progerin expression) on alternative splicing (AS) using exon microarrays to interrogate the differential exon usage of the entire genome of HGPS mice (postnatal day 24 and 35) and their wild-type litter mates. Our results suggests that early expression of progerin impairs developmental splicing but that as progerin accumulates, the number of genes with AS increases, similar to what is observed in aging wild-type mice. This dataset is one of the 2 datasets in the overall study. An additional data set series is available with exon expression analysis of aging wild-type mice to analyze the effect of age on alternative splicing during physiological aging. The two datasets are linked together in the SuperSeries GSE67289. A link to the SuperSeries is available at the bottom of this page.
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| Overall design |
16 skin keratinocyte samples from 2 different age groups: postnatal day 24 and postnatal day 35, from 8 HGPS samples and 8 genotype negative (wild-type) littermates.
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| Contributor(s) |
Rodriguez SA, Brodin D, Eriksson M, McKenna T |
| Citation(s) |
26685868 |
| Submission date |
Mar 25, 2015 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Maria Eriksson |
| E-mail(s) |
maria.eriksson.2@ki.se
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| Organization name |
Karolinska Institutet
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| Department |
Biosciences and Nutrition
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| Lab |
Maria Eriksson
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| Street address |
Hälsovägen 7
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| City |
Huddinge |
| ZIP/Postal code |
14183 |
| Country |
Sweden |
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| Platforms (1) |
| GPL6193 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version] |
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| Samples (16)
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| GSM1643884 |
keratinocytes, postnatal day 24, from transgenic mouse expressing progerin and lamin A, biological rep1 |
| GSM1643885 |
keratinocytes, postnatal day 24, from transgenic mouse expressing progerin and lamin A, biological rep2 |
| GSM1643886 |
keratinocytes, postnatal day 24, from transgenic mouse expressing progerin and lamin A, biological rep3 |
| GSM1643887 |
keratinocytes, postnatal day 24, from transgenic mouse expressing progerin and lamin A, biological rep4 |
| GSM1643888 |
keratinocytes, postnatal day 24, from genotype negative littermate, biological rep1 |
| GSM1643889 |
keratinocytes, postnatal day 24, from genotype negative littermate, biological rep2 |
| GSM1643890 |
keratinocytes, postnatal day 24, from genotype negative littermate, biological rep3 |
| GSM1643891 |
keratinocytes, postnatal day 24, from genotype negative littermate, biological rep4 |
| GSM1643892 |
keratinocytes, postnatal day 35, from transgenic mouse expressing progerin and lamin A, biological rep1 |
| GSM1643893 |
keratinocytes, postnatal day 35, from transgenic mouse expressing progerin and lamin A, biological rep2 |
| GSM1643894 |
keratinocytes, postnatal day 35, from transgenic mouse expressing progerin and lamin A, biological rep3 |
| GSM1643895 |
keratinocytes, postnatal day 35, from transgenic mouse expressing progerin and lamin A, biological rep4 |
| GSM1643896 |
keratinocytes, postnatal day 35, from genotype negative littermate, biological rep1 |
| GSM1643897 |
keratinocytes, postnatal day 35, from genotype negative littermate, biological rep2 |
| GSM1643898 |
keratinocytes, postnatal day 35, from genotype negative littermate, biological rep3 |
| GSM1643899 |
keratinocytes, postnatal day 35, from genotype negative littermate, biological rep4 |
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| This SubSeries is part of SuperSeries: |
| GSE67289 |
The effect of age and progerin expression on alternative splicing in selected tissues in mice |
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| Relations |
| BioProject |
PRJNA279417 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE67288_RAW.tar |
352.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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