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| Status |
Public on Mar 27, 2015 |
| Title |
Patient-derived primary xenografts in the preclinical development of novel targeted therapies for bladder cancer |
| Platform organism |
Homo sapiens |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Purpose: While molecular targeted therapy has revolutionized the treatment of many cancers, little progress has been made in the development of novel therapies for muscle invasive bladder cancer (MIBC). Here we report on the establishment and characterization of patient-derived primary MIBC xenografts
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| Overall design |
Tumor fragments derived from 7 patients with MIBC were grafted under the renal capsule of NOD-SCID mice and subsequently transplanted to further mice over multiple generations. Patient tumor and xenograft tissue were processed for analysis of , gene expression by microarray, and expression of select potential target pathways by immunohistochemistry (IHC).
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| Contributor(s) |
Jager W, Xue H, Hayashi T, Janssen C, Awrey S, Anderson S, Haegert A, Erho N, Alshalalfa M, Fazli L, Li E, Davicioni E, Wang YZ, Black PC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 26, 2015 |
| Last update date |
Mar 27, 2015 |
| Contact name |
Mohammed Alshalalfa |
| E-mail(s) |
mohamed@genomedx.com
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| Organization name |
GenomeDx
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| Street address |
water st
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| City |
vancouver |
| State/province |
bc |
| ZIP/Postal code |
V6B 1B8 |
| Country |
Canada |
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| Platforms (1) |
| GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA279489 |
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