|
| Status |
Public on Nov 02, 2015 |
| Title |
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells.
|
| |
|
| Overall design |
ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
|
| |
|
| Contributor(s) |
Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL |
| Citation(s) |
26320100 |
| Submission date |
Jun 03, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Peter van Galen |
| E-mail(s) |
petervangalen@gmail.com, pvangalen@bwh.harvard.edu
|
| Organization name |
Brigham and Women's Hospital / Broad Institute of MIT and Harvard
|
| Department |
Hematology
|
| Lab |
Van Galen Lab
|
| Street address |
4 Blackfan Circle
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (72)
|
|
| This SubSeries is part of SuperSeries: |
| GSE71422 |
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression |
|
| Relations |
| BioProject |
PRJNA285772 |
| SRA |
SRP059032 |
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