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| Status |
Public on Oct 23, 2015 |
| Title |
Positional proteomics reveals differences in N-terminal proteoform stability |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
To understand the impact of alternative translation initiation on a proteome, we performed the first study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes. Overall, we monitored the stability of 1,941 human N-terminal proteoforms, including 147 N-terminal proteoform pairs that originate from alternative translation initiation, alternative splicing or incomplete processing of the initiator methionine.
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| |
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| Overall design |
Ribosome profiling of lactimidomycin and cycloheximide treated human Jurkat T-lymphocytes
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| |
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| Contributor(s) |
Gawron D, Ndah E, Gevaert K, Van Damme P |
| Citation(s) |
26893308 |
| BioProject |
PRJNA299254 |
| Submission date |
Oct 22, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Petra Van Damme |
| E-mail(s) |
petra.vandamme@ugent.be
|
| Phone |
+3292649279
|
| Organization name |
VIB
|
| Street address |
Albert Baertsoenkaai 3
|
| City |
Gent |
| ZIP/Postal code |
9000 |
| Country |
Belgium |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| SRA |
SRP065022 |
