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| Status |
Public on Feb 01, 2016 |
| Title |
Gene expression profiling in metabolically heterogeneous human lung tumors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the impact of genetic and environmental factors that influence cancer cell metabolism in vivo, we conducted intra-operative 13C-glucose infusions in NSCLC patients. We determined that regional glucose metabolism was correlated with tumor perfusion as assessed by pre-surgical dynamic gadolinium enhancement. Tumors or tumor regions showing high or low perfusion were collected and subjected to RNA-seq analysis.
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| Overall design |
RNA-seq analysis was performed to evaluate gene transcriptional levels in human non-small cell lung cancer (NSCLC) tissues showing high or low perfusion as measured by dynamic contrast-enhanced (DCE) MRI.
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| |
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| Contributor(s) |
Faubert B, Hensley C, Ni M, DeBerardinis R |
| Citation(s) |
26853473 |
| Submission date |
Oct 29, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Min Ni |
| E-mail(s) |
min.ni@utsouthwestern.edu
|
| Organization name |
UT Southwestern Medical Center
|
| Department |
Children's Research Institute
|
| Lab |
DeBerardinis Lab
|
| Street address |
6000 Harry Hines Blvd
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA300542 |
| SRA |
SRP065491 |
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