|
| Status |
Public on Aug 23, 2016 |
| Title |
Molecular Signatures Associated with ZIKV Exposure in Human Cortical Neural Progenitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients.
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| |
|
| Overall design |
Gene Expression Analyses of the cells infected with different flaviviruses
|
| |
|
| Contributor(s) |
Jin P |
| Citation(s) |
27580721 |
| Submission date |
Apr 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Peng Jin |
| E-mail(s) |
peng.jin@emory.edu
|
| Phone |
4047273729
|
| Organization name |
Emory University
|
| Department |
Human Genetics
|
| Lab |
Jin Lab
|
| Street address |
615 Michael St., Rm 325
|
| City |
Atlanta |
| State/province |
Georgia |
| ZIP/Postal code |
30322 |
| Country |
USA |
| |
|
| Platforms (3) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL15520 |
Illumina MiSeq (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA318898 |
| SRA |
SRP073493 |
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