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| Status |
Public on Jul 10, 2016 |
| Title |
Assay for Transposase-Accessible Chromatin with high throughput sequencing (ATAC-Seq) reveals lncRNA MANTIS important for the angiogenic function of endothelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The angiogenic function of endothelial cells is tightly regulated but the impact of long non-coding RNAs (lncRNA) remains unclear. The lncRNA yielded to be an epigenetically restricted endothelial lncRNAs. Here, the chromatin accessibility after knockdown of MANTIS was investigated. It revealed changes on chromatin accessibility on several promoters which are known to be important for endothelial angiogenic function.
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| |
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| Overall design |
ATAC-seq profiles after knockdown with scrambled or MANTIS siRNA in human umbilical vein endothelial cells (HUVEC).
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| Contributor(s) |
Leisegang MS, Künne C, Günther S, Brandes RP |
| Citation(s) |
28351900 |
| Submission date |
Jun 16, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Matthias S Leisegang |
| Organization name |
Goethe-University
|
| Department |
Institute for Cardiovascular Physiology
|
| Street address |
Theodor-Stern-Kai 7
|
| City |
Frankfurt |
| ZIP/Postal code |
60590 |
| Country |
Germany |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA325880 |
| SRA |
SRP076664 |
