Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing
Summary
ERK activates ERG-mediated prostate cancer specific gene expression program by phopshorylation induced dissociation of PRC2 complex
Overall design
ChIP-Seq of transcription factor ERG and its co-repressor EZH2 RNA-seq of polyA selected RNA from RWPE1 cells expressing either empty vector, ERG-WT, ERG-S96A and ERG-S96E
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