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| Status |
Public on Mar 08, 2017 |
| Title |
Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study we investigated the effect of normal chow (0 % cholesterol) or a semisynthetic diet (high sugar, 0.02 % cholesterol) fed to mice lacking either Mc4r, Ldlr or both and wildtype animals (total of 4 genotypes) by generating an expression profile of their livers after 6 months by RNA sequencing.
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| Overall design |
We investigated mice lacking either Mc4r, Ldlr or both and wildtype animals fed with normal chow or a semisynthetic diet with 10 replicates for each of the 8 resulting groups (4 genotypes * 2 diets).
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| Contributor(s) |
Schöneberg T, Schulz A, Thiery J, Ricken A, Schiller J, Kiess W, Teupser D, Huster D, Garten A, Penke M, Popkova Y, Lede V, Meusel A, Franke C |
| Citation(s) |
28030540 |
| Submission date |
Oct 07, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Torsten Schöneberg |
| Organization name |
Leipzig University
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| Department |
Institute of Biochemistry, Medical Faculty
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| Street address |
Johannisallee 30
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| City |
Leipzig |
| ZIP/Postal code |
04103 |
| Country |
Germany |
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| Platforms (1) |
| GPL16173 |
Illumina HiScanSQ (Mus musculus) |
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| Samples (80)
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| Relations |
| BioProject |
PRJNA347337 |
| SRA |
SRP090989 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE87743_read-count-matrix.txt.gz |
2.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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