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| Status |
Public on Mar 07, 2017 |
| Title |
ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing (ChIP-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We performed a transcriptomic and epigenomic study in patient-derived B-cell lines to investigate the genome-scale effects of DNMT3B dysfunction. We highlighted that altered intragenic CpG-methylation impairs multiple aspects of transcriptional regulation, like alternative TSS usage, antisense transcription and exon splicing.
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| |
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| Overall design |
Samples used in this study correspond to B-lymphoblastoid cell lines (B-LCL) derived from peripheral blood of individuals affected by ICF1 syndrome and healthy individuals
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| |
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| Contributor(s) |
Gagliardi M, Angelini C, Matarazzo MR |
| Citation(s) |
28334849 |
| Submission date |
Mar 06, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Miriam Gagliardi |
| E-mail(s) |
miriam_gagliardi@psych.mpg.de
|
| Organization name |
Max Planck Institute of Psychiatry
|
| Street address |
Kraepelinstrasse 2-10
|
| City |
Munich |
| State/province |
Bayern |
| ZIP/Postal code |
80804 |
| Country |
Germany |
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| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL13393 |
AB SOLiD 4 System (Homo sapiens) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE95747 |
ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing |
|
| Relations |
| BioProject |
PRJNA378321 |
| SRA |
SRP101527 |
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