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RUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
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The MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in MLLr AML
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Gene expression analysis of leukemic samples in C57BL6 mice
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Mixed lineage leukemia fusion protein induction of acute leukemia: bone marrow cells
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Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins
PubMed Full text in PMC Similar studies
Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [II]
Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [I]
MLL-AF4 binds directly to a BCL-2 specific enhancer and impacts H3K27 acetylation
Instructive role of MLL fusion proteins revealed by a faithful model of t(4;11) proB acute lymphoblastic leukemia
PubMed Similar studies SRA Run Selector
A faithful in vivo model of human MLL-AF4 proB acute lymphoblastic leukemia
PubMed Similar studies Analyze with GEO2RSRA Run Selector
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
ATAC-Seq of foetal blood progenitors
Inhibition of MEK and ATR induces synergistic killing of a Mll-Af4 B-ALL model harboring activated Ras mutation
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
PubMed Full text in PMC Similar studies Analyze with GEO2R
Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow
Genome-wide analysis of H3K79 dimethylation in normal and MLL-AF4 leukemic pre-B cells
Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL
Expression profiling of activated or control 5-FU bone marrow from MLL-AF4stop knockin mice
Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts
DNA methylation in infant ALL
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