GEO DataSets

(Submitter supplied) Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into apical lumen via cell competition. However, it remains elusive which internal or external factors compromise cell competition and provoke oncogenesis. Here, we examine the effect of sequential accumulation of gene mutations mimicking multi-sequential carcinogenesis on RasV12-induced cell competition. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL15379

6 Samples

Download data: TXT

(Submitter supplied) Newly emerging transformed cells carrying genetic defects, including the active Ras mutant, are apicall extruded when surrounded by normal epithelial cells. This biological phenomenon is termed as cell competition. It remains elusive which factors prime RasV12-transformed cells to be expelled via cell competition. Here, We performe microarray analysis to search for molecules whose expression is changed in RasV12 cells surrounded by normal cells.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL15379

6 Samples

Download data: TXT

(Submitter supplied) Cell competition is a social cellular phenomenon in which unfit cells are selectively eliminated by wild-type (WT) cells. Although recent studies show that mechanical forces induce competitive cell-cell interactions, it remains largely unknown how unfit cells are sensed and mechanically eliminated. Here, we report that MDCK cells depleted of the polarity gene scribble (scribKD cells) secrete FGF21 to drive cell competition. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL13605

6 Samples

Download data: TXT

(Submitter supplied) Constitutive activation of the anti-apoptotic NF-κB signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL) that is characterized by adverse survival. Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that connects B-cell receptor (BCR) signaling to the canonical NF-κB pathway. We asked how far additional downstream processes are activated and contribute to the oncogenic potential of DLBCL-derived CARMA1 mutants. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

10 Samples

Download data: TXT

(Submitter supplied) Wound healing is a complex process that repairs organ-tissues including skin after injury. Cell migration is an important process of wound healing and fibroblast growth factor bFGF has been reported to accelerate cell migration. However, knowledge of how bFGF regulates cell migration is limited. Here, we used human foreskin fibroblast primary cells and RNA-Seq based transcriptome analysis to isolate bFGF-regulating signal pathways that regulate cell migration. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17303

6 Samples

Download data: TXT

(Submitter supplied) While growth factor-independent signaling and proliferation are well-established hallmarks of cancer, little is known regarding growth factor-independent changes in gene expression which occur downstream from oncogenes. The PI3K pathway is one of the most commonly misregulated signaling pathways in human cancers. Here, MCF10A cells expressing the two most common PI3K mutations, PIK3CA E545K and H1047R, were used to identify the repertoire of genes altered by oncogenic PI3K mutations following growth factor deprivation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10481

39 Samples

Download data