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Series GSE130068 Query DataSets for GSE130068
Status Public on Apr 29, 2019
Title Genomewide Association Study of Tacrolimus Pharmacokinetics Identifies Novel Single Nucleotide Polymorphisms in Convalescence Phase and Stabilizing Phase of Liver function Respectively
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Following liver transplantation, the liver function of a patient is gradually restored over a period of time, which is divided into a convalescence period (CP) and a stabilizing period (SP). Tacrolimus (TAC), a commonly-used immunosuppressant for the prevention of organ rejection, shows variability in plasma concentration in these patients as a result of variation in its metabolism. The effects of genetic and clinical factors on its plasma levels seem to differ in the CP and SP. To establish a model explaining TAC trough concentration variation between individuals in both the CP and SP, we conducted a retrospective, single-center, discovery study, involving 115 pairs of patients (115 donors and 115 matched recipients) who had undergone liver transplantation. Donors and recipients were genotyped by genomewide association study (GWAS) using an exome chip.
 
Overall design Paired 115 liver transplant patients (115 donor + 115 recipient livers)
 
Contributor(s) Liu Y, Peng Z
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Apr 19, 2019
Last update date Apr 29, 2019
Contact name Yuan Liu
E-mail(s) paradisetong@163.com
Phone 18930207891
Organization name Shanghai Jiaotong University school of medicine
Street address No.277 Chongqingnan Road, Huangpu Distict,Shanghai
City Shanghai
State/province Shanghai
ZIP/Postal code 200080
Country China
 
Platforms (1)
GPL26511 Infinium Human Exome-12 v1.2 BeadChip
Samples (230)
GSM3731268 1S: EXOME of homo sapiens, recipient liver
GSM3731269 2S: EXOME of homo sapiens, recipient liver
GSM3731270 3S: EXOME of homo sapiens, recipient liver
Relations
BioProject PRJNA533786

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE130068_Matrix_processed.txt.gz 174.7 Mb (ftp)(http) TXT
GSE130068_Matrix_signal_intensities.txt.gz 134.8 Mb (ftp)(http) TXT
GSE130068_RAW.tar 948.9 Mb (http)(custom) TAR (of IDAT)
Processed data are available on Series record
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