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| Status |
Public on Apr 24, 2024 |
| Title |
Potential utility of L-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We examined the potential utility of L-carnitine for alleviating metabolic dysfunction-associated steatohepatitis (MASH) and preventing the development of hepatocellular carcinoma.
Short-term L-carnitine administration ameliorated MASH through its anti-inflammatory effects.
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| Overall design |
L-carnitine (2 g/day) was administered to 11 MASH patients for 10 weeks, and blood liver function tests were performed. Five patients received a serial liver biopsy, and liver histology and hepatic gene expression were evaluated using this tissue. 10-weeks L-carnitine administration significantly improved serum alanine transaminase and aspartate transaminase levels along with a histological improvement of the nonalcoholic fatty liver disease activity score, while steatosis and fibrosis were not improved. Gene expression profiling revealed a significant improvement of the inflammation and pro-fibrotic gene signature as well as the recovery of lipid metabolism.
*** According to the submitter raw data are not available for this submission because the HDD was broken and we lost original CEL files. ***
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| Contributor(s) |
Lyu J, Okada H, Sunagozaka H, Kawaguchi K, Shimakami T, Nio K, Murai K, Shirasaki T, Yoshida M, Arai K, Yamashita T, Tanaka T, Harada K, Takamura T, Kaneko S, Yamashita T, Honda M |
| Citation(s) |
38619434 |
| Submission date |
Mar 19, 2024 |
| Last update date |
Apr 24, 2024 |
| Contact name |
Masao Honda |
| E-mail(s) |
mhondag@gmail.com
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| Phone |
0762652243
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| Organization name |
Kanazawa University
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| Department |
Gastroenterology
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| Street address |
Takara-Machi 13-1
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| City |
Kanazawa |
| ZIP/Postal code |
920-8641 |
| Country |
Japan |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA1089610 |
| Supplementary data files not provided |
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