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| Status |
Public on Jul 23, 2013 |
| Title |
Gene expression data in CD4+ and CD8+ cells in sarcoidosis patients following antimycobacterial therapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Many chronic cutaneous diseases associated with microbial antigens demonstrate clinical progression due to T cell hyporesponsiveness. Appropriate antimicrobial therapy restores T cell function, leading to clinical resolution. Due to the association of sarcoidosis with mycobacterial antigens, we compared the efficacy of antimycobacterial therapy with placebo in chronic cutaneous sarcoidosis.
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| Overall design |
We conducted a randomized, placebo-controlled, single-blind trial on chronic cutaneous sarcoidosis subjects. Participants received the oral CLEAR regimen: Levofloxacin 750 mg on day 1, then 500 mg daily, Ethambutol 1200 mg daily, Azithromycin 500 mg on day 1, then 250 mg daily, and Rifampin 300 mg daily, or a comparative placebo regimen, for a total of 8 weeks, with a 180 day follow-up. Participants were monitored for absolute change in lesion diameter and decrease in granulomas burden upon completion of therapy.
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| Contributor(s) |
Pandit KV, Drake W, Kaminski N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 24, 2012 |
| Last update date |
Oct 11, 2016 |
| Contact name |
Kusum Vijay Pandit |
| E-mail(s) |
panditkusum@yahoo.com
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| Phone |
412-624-9046
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| Organization name |
University of Pittsburgh
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| Department |
Medicine-PACCM
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| Street address |
200, Lothrop street, W1200-25A Biomedical Science Tower
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| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (20)
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| GSM972931 |
CD4+ T cells, baseline, biological replicate 1 |
| GSM972932 |
CD4+ T cells, post treatment, biological replicate 1 |
| GSM972933 |
CD8+ T cells, baseline, biological replicate 1 |
| GSM972934 |
CD8+ T cells, post treatment, biological replicate 1 |
| GSM972935 |
CD4+ T cells, baseline, biological replicate 2 |
| GSM972936 |
CD4+ T cells, post treatment, biological replicate 2 |
| GSM972937 |
CD8+ T cells, baseline, biological replicate 2 |
| GSM972938 |
CD8+ T cells, post treatment, biological replicate 2 |
| GSM972939 |
CD4+ T cells, baseline, biological replicate 3 |
| GSM972940 |
CD4+ T cells, post treatment, biological replicate 3 |
| GSM972941 |
CD8+ T cells, baseline, biological replicate 3 |
| GSM972942 |
CD8+ T cells, post treatment, biological replicate 3 |
| GSM972943 |
CD4+ T cells, baseline, biological replicate 4 |
| GSM972944 |
CD4+ T cells, post treatment, biological replicate 4 |
| GSM972945 |
CD8+ T cells, baseline, biological replicate 4 |
| GSM972946 |
CD8+ T cells, post treatment, biological replicate 4 |
| GSM972947 |
CD4+ T cells, baseline |
| GSM972948 |
CD4+ T cells, placebo treatment |
| GSM972949 |
CD8+ T cells, baseline |
| GSM972950 |
CD8+ T cells, placebo treatment |
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| Relations |
| BioProject |
PRJNA171238 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE39606_RAW.tar |
62.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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